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Department of Veterinary Medicine

Cambridge Veterinary School

Studying at Cambridge

 

Dr Arijit Kumar Das

Dr Arijit Kumar Das

Research associate


Biography:

Being interested in how the biological machine works, I obtained my Bachelor’s degree in Zoology (H) from Calcutta University, India, (2005) and then a Master’s degree in Biotechnology from Bangalore University, India, (2007). I then went on to study transcriptional biology of the human pathogen Mycobacterium tuberculosis for my PhD from Institute of Microbial Technology-CSIR, India, (2013).

During the next phase of my research career as a post-doctoral fellow, I joined the lab of Dr James Locke in 2013, at the Sainsbury Laboratory, University of Cambridge, to study the single cell transcriptional dynamics of cyanobacteria. I joined Prof Clare Bryant’s group in 2017 to study the process of host pathogen interaction in Salmonella infection.

 

Subject groups/Research projects

Infection and Immunity:

Research Interests

My primary research interest lies in deciphering the mechanism of host pathogen interaction in infection. I am interested in understanding how the pathogenic bacteria respond and adapt to the host defences and how the host defends itself from ever evolving bacteria. I am interested in understanding what role phenotypic heterogeneity plays in deciding the fate of infections. I want to study the host pathogen interactions in the light of phenotypic heterogeneity and devise novel intervention strategies.

Keywords

  • Host-pathogen interaction
  • Host pathogen interaction
  • Phenotypic heterogeneity
  • Systems Biology
  • Salmonella

Key Publications

-       Das, AK+, Pathak, A+, Sinha, A., Datt, M., Singh, B., Karthikeyan, S. and Sarkar, D. A single amino acid substitution in the C terminus of PhoP determines DNA binding specificity of the virulence-associated response regulator from Mycobacterium tuberculosis. J. Mol. Biol. (2010) 398, 647–656.

-       Goyal R+, Das AK+, Singh R, Singh PK, Korpole S, Sarkar D. Phosphorylation of PhoP plays direct regulatory role in lipid biosynthesis of Mycobacterium tuberculosis. J Biol Chem. (2011). 286:45197-208.

-       Das AKKumar VA, Sevalkar RR, Bansal R, Sarkar D. Unique N-terminal arm of Mycobacterium tuberculosis PhoP plays an unusual role in its regulatory function. J Biol Chem. (2013). 288:29182-92

-       Singh R, Kumar VA, Das AKBansal R, Sarkar D. A transcriptional co-repressor regulatory circuit controlling the heat-shock response of Mycobacterium tuberculosis. Mol Microbiol. (2014).94:450-65.

-       Martins BMC+, Das AK+, Locke JCW.   Frequency doubling in the cyanobacterial circadian clock. Mol Sys Biol (2016). 12 (12) 896.

(+ Equal contribution)