Chun-Yen completed his BSc degree (Biological Sciences) at University of Liverpool in June 2015. He joined Professor Justin Hsuan’s team at UCL (Royal Free Hospital, London) in Oct 2015 as an MRes student working on exploring extracellular effect of thymosin-beta4 and an oxidised isomer on PI3K/Akt/mTOR signalling pathway on Neuroendocrine Tumour Cells.
Currently, he is in the 1st year of his PhD, working in association with Dr. John Gibson to study the pathophysiology of human sickle cell disease. During Chun-Yen’s PhD study, he will mainly focus on four areas: (1) Identify physiological conditions which maximally activate K-Cl co-transporter (KCC) in red cells from SCD patients; (2) Investigate the role of intracellular Mg2+ and the activity red cell Mg2+ transport systems in regulation of KCC; (3) Identify regulatory phosphoresidues altered in SCD which result in abnormal activity of KCC; (4) Investigate potential inhibitors of KCC activity.
Subject groups/Research projects