2016 MPhil Veterinary Science, Department of Veterinary Medicine, University of Cambridge, UK
2014-present British Small Animal Veterinary Association
(BSAVA) Post Graduate Programme in Veterinary Ophthalmology
2014-2015 Assistant ophthalmologist at Dick White Referrals Veterinary Hospital
2006-2008 Clinical Research Fellowship in Veterinary Ophthalmology at
the M. J. Ryan Veterinary Hospital of the University of Pennsylvania (USA)
2003-2004 Rotating Internship in Small Animal Medicine & Surgery at the M.J. Ryan Veterinary Hospital of the University of Pennsylvania (USA)
Subject groups/Research projects
My Mphil projects is to define keratoconjunctivitis sicca (KCS) (dry eye) in the English Cocker Spaniel (ECS) dog affected xby immune-mediated chronic pancreatitis (CP) by evaluating clinical signs, cytological and specific immune-mediated changes.
CP in the ECS shows similarities to human type 1 autoimmune CP (AIP), where the immune system attacks kidney, liver, tear ducts and other organs as well as the pancreas. This form is associated with elevation in serum IgG4 levels and increased IgG4-expressing plasma cells within the lesions and increase serum antibodies against carbonic anhydrase Type II. The causes of human AIP remain poorly understood. The antigen or antigens driving the diseases are unknown.
As in affected people, ECS with CP demonstrate duct-centred infiltrates of T-lymphocytes and a predominance of IgG4+ plasma cells has been demonstrated in pancreatic and renal histology. Affected dogs may also have other immune-mediated diseases such as KCS.
This study will: