1991-1994 BSc Hons 2(i) Biology, University of Wales, Aberystwyth
1994-1995 Postgraduate diploma in Biological Electron Microscopy, University of Wales, Aberystwyth
2005-2009 PhD in Veterinary Medicine, Department of Veterinary Medicine, University of Cambridge
2009-present Research Associate, Department of Veterinary Medicine, University of Cambridge
Subject groups/Research projects
I am a postdoctoral researcher with a long-standing interest in protein misfolding neurodegenerative diseases. More recently my focus has widened to the field of pattern recognition receptors (PRR) and their role in innate immunity. The remit of my current project is to investigate the interplay between PRR signalling and the Parkinson’s disease associated protein, LRRK2.
Investigating the role of Toll-like receptors (TLRs) and LRRK2 in vertebrate microglia for the initiation and progression of Parkinson’s Disease.
Collaborators outside this directory
Yang, S., Thackray, A.M., Hopkins, L., Monie, T.P., Burke, D.F. and Bujdoso, R. (2014) Polymorphisms at amino acid residues 141 and 154 influence conformational variation in ovine PrP. Biomed Res Int. 2014:372491
Man, S.M., Hopkins, L.J., Nugent, E., Cox, S., Glück, I.M., Tourlomousis, P., Wright, J.A., Cicuta, P., Monie, T.P. and Bryant CE. (2014) Inflammasome activation causes dual recruitment of NLRC4 and NLRP3 to the same macromolecular complex. Proc Natl Acad Sci U S A 2014 111 (20) 7403-8.
Jabir, M.S., Ritchie, N.D., Li, D., Bayes, H.K., Tourlomousis, P., Puleston, D., Lupton, A., Hopkins, L., Simon, A.K., Bryant, C. and Evans, T.J. (2014) Caspase-1 cleavage of the TLR adaptor TRIF inhibits autophagy and β-interferon production during Pseudomonas aeruginosa infection. Cell Host Microbe 15(2) 214-27.
Man, S.M., Tourlomousis, P., Hopkins, L., Monie, T.P., Fitzgerald, K.A. and Bryant, C.E. (2013) Salmonella infection induces recruitment of Caspase-8 to the inflammasome to modulate IL-1β production. Journal of Immunology 191 (10) 5239-46.
Herre J., Grönlund, H., Brooks, H., Hopkins, L., Waggoner, L., Murton, B., Gangloff, M., Opaleye, O., Chilvers, E.R., Fitzgerald, K, Gay, N., Monie, T. and Bryant, C. (2013) Allergens as immunomodulatory proteins: the cat dander protein Fel d 1 enhances TLR activation by lipid ligands. Journal of Immunology 191(4) 1529-35.
Irvine, K.L., Hopkins, L.J., Gangloff, M. and Bryant C.E. (2013) The molecular basis for recognition of bacterial ligands at equine TLR2, TLR1 and TLR6.
Veterinary Research 44:50
Thackray, A.M., Hopkins, L., Lockey, R., Spiropoulos, J. and Bujdoso, R. (2012) Propagation of ovine prions from poor transmitter scrapie isolates in ovine PrP transgenic mice. Experimental and Molecular Pathology 92 (1) 167-174.
Thackray, A.M., Hopkins, L., Lockey, R., Spiropoulos, J. and Bujdoso, R. (2011) Emergence of multiple prion strains from single isolates of ovine scrapie. Journal of General Virology 92 (Pt 6) 1482-91.
Thackray, A.M., Hopkins, L., Spiropoulos, J. and Bujdoso, R. (2008) Molecular and transmission characteristics of primary-passaged ovine scrapie isolates in conventional and ovine PrP transgenic mice. Journal of Virology 82 11197-207.
Thackray, A.M., Hopkins, L., Klein, M.A. and Bujdoso, R. (2007) Mouse-adapted ovine scrapie prion strains are characterized by different conformers of PrPSc. Journal of Virology 81 12119-27.
Barnard, G., Hopkins, L., Moorthie, S., Seilly, D., Tonks, P., Dabaghian,R., Clewley,J., Coward, J. and McConnell, I. (2007) Direct Detection of Disease-Associated Prions in Brain and Lymphoid Tissue Using Antibodies Recognizing the Extreme N-terminus of PrPC. Prion 1 121-127.
Thackray, A.M., Hopkins, L. and Bujdoso, R. (2007) Proteinase K-sensitive disease-associated ovine prion protein revealed by conformation-dependent immunoassay. Biochemical Journal 401 475-83.
Davies, M.L., Hopkins, L.J., Halliday, S., Houston, F., Hunter, N. and McConnell, I. (2004) Architecture of secondary lymphoid tissue in sheep experimentally challenged with scrapie. Immunology. 111(2) 230-6.