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Department of Veterinary Medicine

Cambridge Veterinary School

Studying at Cambridge

 

Dr John Henry Stockley

Dr John Henry Stockley

Postdoctoral Researcher in Neuroscience


Biography:

I am a molecular cell biologist working in the group of Dr. Ragnhildur Karadottir. I gained my PhD. in Biochemistry from University College Cork in Ireland where my work focused on enzyme expression and activities in Alzheimer's disease. My current research is focused on understanding the communication between neurons and central nervous system (CNS) progenitors. I am using and developing advanced techniques such as optogenetics and live cell imaging in cell culture models to study this.

Subject groups/Research projects

Neurosciences:

Research Interests

The central nervous system is split 50:50 into grey matter and white matter. I am interested in the formation and maintenance of white matter by myelinating oligodendrocytes and their progenitors OPCs. Diseases associated with impaired myelin maintenance include Multiple Sclerosis, luekodystrophies, stroke and cerebral palsy. I am using in vitro systems to mimic their environment in vivo and gain understanding and control of their fate and function. I am also interested in the application of light to control living cells (optogenetics) to study them (live cell imaging) and sort them (FACs). I am currently addressing the role of synaptic input to OPCs using optogenetics

Keywords

  • Multiple Sclerosis
  • Myelination
  • Stem cells
  • Optogenetics