Department of Veterinary Medicine

Cambridge Veterinary School

Research in Veterinary Medicine

Simon D W Frost

Position(s): University Senior Lecturer - Link to CV

Email: sdf22@cam.ac.uk

Tel.: +44 (0)1223 764201

Other relevant links

Research description

My research interests focus on the use of mathematical and statistical modeling to understanding the dynamics and evolution of infectious diseases such as HIV, hepatitis C and influenza A. Long-term goals involve diversifying to study other viral systems, and the integration of mulitple modalities of data as more health-related data are made available electronically, and as increasing computational power permits more sophisticated statistical analyses. Current projects include the statisical modeling of evolutionary processes acting on genetic sequences, modeling viral and immune dynamics, designing diagnostics for viral infections, mining of large clinical databases, and investigating novel means of capturing social, sexual and disease transmission networks.

Main collaborators

  • Sergei Kosakovsky Pond, UCSD
  • Douglas Richman, UCSD
  • Susan Little, UCSD
  • Gerond Lake-Bakaar, Harvard
  • Todd Allen, Harvard
  • Andrew Leigh Brown, Edinburgh
  • Douglas Heckatorn, Cornell
  • Steven Shoptaw, UCLA

 

Key publications since 2001

  • Drumright, L.N. and Frost, S.D.W. 2008 Sexual networks and the transmission of drug resistant HIV. Current Opinions in Infectious Diseases 21: 644-652
  • Frost, S.D.W., Trkola, A., Gunthard, H.F. and Richman, D.D. 2008 Antibody responses in primary HIV-1 infection. Current Opinions in HIV AIDS 3: 45-51
  • Frost, S.D.W. 2007 Using sexual affiliation networks to describe the sexual structure of a population. Sex. Transm. Inf. 83: (suppl 1): 137-142
  • Poon, A.F.Y., Kosakovsky Pond, S.L., Bennett, P., Richman, D.D., Leigh Brown, A.J. and Frost, S.D.W. 2007 Adaptation to human populations is revealed by within-host polymorphism in HIV-1 and Hepatitis C virus. PLoS Pathog. 3:e45
  • Poon, A.F.Y., Lewis, F.I., Kosakovsky Pond, S.L. and Frost, S.D.W. 2007 Detection of 'N-linked' glycan interactions by phylogenetic and Bayesian network analysis og HIV-1 envelope sequesces. PLoS Comp. Biol. 3:e45
  • Frost, S.D.W. Brouwer, K.C., Firestone, M.A., Ramos, R., Ramos, M.E., Lozada, R.M., Magis-Rodriquez, C. and Strathdee, S.A. 2006 Respondent driven sampling of injection drug users in two U.S.- Mexico border cities: recruitment dynamics and impact on estimates of HIV and syphilis prevalence. J. Urban Health. 83: (suppl 7): 83-97
  • Kosakovsky Pond, S.L., Posada, D., Gravenor, M.B., Woelk, C.H. and Frost, S.D.W. 2006 Automated phylogenetic detection of recombination using a genetic algorithm. Mol.Biol.Evol. 23: 1891-1901
  • Frost, S.D.W., Wrin, T., Smith, D.M., Kosakovsky Pond, S.L., Liu, Y., Paxinos, E., Chappey, C., Galovich, J., Beauchaine, J., Petropoulos, C.J., Little, S.J. and Richman, D.D. 2005 Neutralizing antibody responses drive the evolution of human immunodeficiency virus type 1 envelope during recent HIV infection. Proc.Natl.Acad.Sci. 102: 18514-18519
  • Frost, S.D.W., Liu, Y., Kosakovksy Pond, S.L., Chappey, C., Liu, Y., Wrin, T., Petropoulos, C.J., Little, S.J. and Richman, D.D. 2005 Characterization of HIV-1 envelope variation and neutralizing antibody responses during transmission of HIV-1 subtype B. Journal of Virology 79: 6523-6527
  • Kosakovsky Pond, S.L. and Frost, S.D.W., 2005 Not so different after all: a comparison of methods for detecting amino acid sites under selection. Mol. Biol. Evol. 22: 1208-1222