Research in Veterinary Medicine
Peter Lachmann
Position(s): Emeritus Sheila Joan Smith Professor of Immunology
Email: pjl1000@cam.ac.uk
Tel.: +44 (0)1223 766242
Research description
No longer runs his own laboratory. Devising therapeutic interventions that modify the actions of the complement system
Main collaborators
- Dr Richard Smith, Dept of Medicine, Cambridge and Kings College London
Key publications since 2001
- Fernie-King BA, Seilly DJ, Binks MJ, Sriprakash KS and Lachmann PJ (2007) Streptococcal DRS (distantly related to SIC) and SIC inhibit antimicrobial peptides, components of mucosal innate immunity: a comparison of their activities. Microbes Infect 9 300-307
- Fernie-King BA, Seilly DJ and Lachmann PJ (2006) Inhibition of antimicrobial peptides by group A streptococci: SIC and DRS. Biochem Soc Trans 34 273-5
- Lachmann P (2006) Complement before Molecular Biology. Mol Immunol 43:496-508
- Binks MJ, Fernie-King BA, Seilly DJ, Lachmann PJ and Sriprakash KS (2005) Attribution of the various inhibitory actions of the streptococcal inhibitor of complement (SIC) to regions within the molecule. J Biol Chem 280(20) 20120-5
- Hiemstra PS, Fernie-King BA, McMichael J, Lachmann PJ and Sallenave J-M (2004) Antimicrobial peptides: mediators of innate immunity as templates for the development of novel anti-infective and immune therapeutics. Curr Pharma Des 10(23) 2891-2905
- Fernie-King, BA, Seilly, DJ and Lachmann, PJ (2004) The interaction of streptococcal inhibitor of complement (SIC) and its proteolytic fragments with the human beta defensins. Immunol 111 444-452
- Lachmann, PJ (2003) Lupus and desoxyribonuclease. Lupus 12 202-206
- Fernie-King BA, Seilly DJ, Davies A and Lachmann PJ (2002) Streptococcal inhibitor of complement inhibits two additional components of the mucosal innate immune system: secretory leukocyte proteinase inhibitor and lysozyme. Infect Immun 70 4908-16
- Fernie-King BA, Seilly DJ, Willers C, Wurzner R Davies A and Lachmann PJ (2001) Streptococcal inhibitor of complement (SIC) inhibits the membrane attack complex by preventing uptake of C567 onto cell membranes. Immunol 103 390-398
- Pickering MC, Botto M, Taylor PR, Lachmann PJ and Walport MJ (2001) Systemic lupus erythematosus, complement deficiency and apoptosis. Adv Immunol 76 227-324