Research in Veterinary Medicine
Jenny Mumford
Position(s): CIDC Director Equine Influenza Research; UK OIE Expert on Equine Influenza; Chairperson Equine Influenza Expert Surveillance Panel
Email: jam80@cam.ac.uk
Tel.: +44 (0)1223 764964
Other relevant links
Research description
Research has focused on aspects of viral infections of horses in particular the epidemiology and control of equine influenza and the molecular basis of virulence of equine herpes virus 1. Data collected from field outbreaks and experimental infections of vaccinated horses has been used to model the likely significance of antigenic drift on the efficacy of equine influenza vaccines. Antigenic cartography has been applied to HI data on antigenic variation among equine H3N8 isolates with a view to improving vaccine strain selection. The molecular basis of the paralytic potential of EHV1 strains collected over a 30 year period has been explored by sequencing variable regions of paralytic and non paralytic strains.
Main collaborators
- Bryan Grenfell, Penn State University USA
- Derek Smith , Dept Zoology , University of Cambridge
- Jules Minke, Merial , France
- Debra Elton , AHT, Newmarket
- Tom Chambers, University of Kentucky
Key publications since 2001
- Mumford JA. Vaccines and viral antigenic diversity. Rev Sci Tech. 2007 Apr;26(1): 69-90.
- Nugent J, Birch-Machin I, Smith KC, Mumford JA, Swann Z, Newton JR, Bowden RJ, Allen GP, Davis-Poynter N. Analysis of equid herpes virus 1 strain variation reveals a point mutation of the DNA polymerase strongly associated with neuropathogenic versus non-neuropathogenic disease outbreaks. J Virol. 2006 Apr;80(8):4047-60.
- Daly JM, Yates PJ, Newton JR, Park A, Henley W, Wood JL, Davis-Poynter N, Mumford JA. Evidence supporting the inclusion of strains from each of the two co-circulating lineages of H3N8 equine influenza virus in vaccines. Vaccine. 2004 Sep 28;22(29-30):4101-9.
- Park AW, Wood JL, Daly JM, Newton JR, Glass K, Henley W, Mumford JA, Grenfell BT. The effects of strain heterology on the epidemiology of equine influenza in a vaccinated population. Proc Biol Sci. 2004 Aug 7;271(1548):1547-55.
- Grenfell BT, Pybus OG, Gog JR, Wood JL, Daly JM, Mumford JA, Holmes EC. Unifying the epidemiological and evolutionary dynamics of pathogens.
- Science. 2004 Jan 16;303(5656):327-32.
- Wood JL, Newton JR, Daly J, Park AW, Mumford JA. It's all in the mix: infection transmission in populations. Equine Vet J. 2003 Sep;35(6):526-8.
- Daly JM, Yates PJ, Browse G, Swann Z, Newton JR, Jessett D, Davis-Poynter N, Mumford JA. Comparison of hamster and pony challenge models for evaluation of effect of antigenic drift on cross protection afforded by equine influenza vaccines. Equine Vet J. 2003 Jul;35(5):458-62.
- Park AW, Wood JL, Newton JR, Daly J, Mumford JA, Grenfell BT. Optimising vaccination strategies in equine influenza.Vaccine. 2003 Jun 20;21(21-22):2862-70.
- Glass K, Wood JL, Mumford JA, Jesset D, Grenfell BT. Modelling equine influenza 1: a stochastic model of within-yard epidemics. Epidemiol Infect. 2002 Jun ;128 (3): 491-502.
- Castillo-Olivares J, de Vries AA, Raamsman MJ, Rottier PJ, Lakhani K, Westcott D, Tearle JP, Wood JL, Mumford JA, Hannant D, Davis-Poynter NJ. Evaluation of a prototype sub-unit vaccine against equine arteritis virus comprising the entire ectodomain of the virus large envelope glycoprotein (G(L)): induction of virus-neutralizing antibody and assessment of protection in ponies. J Gen Virol. 2001 Oct;82(Pt 10):2425-35.