Biography
I am a veterinary neurologist with a DPhil in Clinical Neurosciences from the University of Oxford, where I investigated congenital myasthenic syndromes. I now combine clinic and teaching with clinical research into neuromuscular diseases and disorders of involuntary muscle contraction. My research is supported by PetSavers (BSAVA), CamVet, and the AKC Canine Health Foundation.
Research
My research aims to improve the diagnosis and treatment of neuromuscular diseases and disorders of involuntary muscle contraction in companion animals. Current projects investigate:
- Seronegative myasthenia gravis, a disorder of the neuromuscular junction.
- Acquired idiopathic megaoesophagus, a condition causing loss of oesophageal motility.
- Idiopathic tremor syndrome, a poorly understood movement disorder.
I use molecular, immunological, and electrophysiological approaches to uncover disease mechanisms and develop better diagnostic tools. By leveraging naturally occurring diseases in dogs, my work seeks to inform therapeutic strategies for both veterinary and human patients.
Publications
Vanhaesebrouck A, Vandenberghe H, Ives E, Granger N. Repetitive nerve stimulation. In: A practical guide to electrodiagnosis in dogs and cats. Vandenberghe H, Ives E, Granger N (Eds). Libri. 1st edition, 2025
Xavier Dos Santos R, Waelkens J, Crawford A, Khan S, Sami S, Gomes S, Van Ham A, Van Soens I, Cornelis I, Canning J, Fenn J, Waters P, Bhatti S, Vanhaesebrouck A (2025). Case series of Canine Myasthenia Gravis: a classification approach with consideration of seronegative dogs. Journal of Veterinary Internal Medicine 39, e70113.
Gomes S, Van Ham L, Van Ham A, Ives E, Vanhaesebrouck A (2020). Canine non-structural megaoesophagus as a clinical sign of underlying neurological disease: 99 cases. Journal of American Animal Hospital Association 56, 7-16.
Vanhaesebrouck A, Webster R, Maxwell S, Rodriguez Cruz P, Cossins J, Wickens J, Liu W, Cetin H, Cheung J, Ramjattan H, Palace J, Beeson D (2019). β2-adrenergic receptor agonists ameliorate the adverse effect of long-term pyridostigmine on neuromuscular junction structure. Brain 142, 3713-3727.
Vanhaesebrouck A, Beeson D (2019). The congenital myasthenic syndromes: expanding genetic and phenotypic spectrums and refining treatment strategies. Current Opinion in Neurology 32, 696-703.
Charalambous M, Bhatti S, Van Ham L, Platt S, Jeffery N, Tipold A, Volk
H, Hasekawa D, Gallucci A, Gandini G, Musteata M, Ives E, Vanhaesebrouck A (2017). Intranasal administration of midazolam via a mucosal administration device for the management of canine status epilepticus: A multicentre randomized parallel-group clinical trial. Journal of Veterinary Internal Medicine 31, 1149-1158.
Monteiro S, Gallucci A, Rousset N, Freeman P, Ives E, Gandini G, Granger N, Vanhaesebrouck A (2016). Medical management of spinal epidural empyema in five dogs. Journal of American Veterinary Medical Association 249, 1180-1186.
Vanhaesebrouck A, Shelton D, Garosi L, Harcourt-Brown T, Couturier J, Behr S, Jeffery ND, Matiasek K, Blakemore W, Granger N (2011). A novel movement disorder in related male Labrador Retrievers characterized by extreme generalized muscle stiffness. Journal of Veterinary Internal Medicine 25, 1089-1096.
Vanhaesebrouck A, Van Soens I, Poncelet L, Duchateau L, Bhatti S, Polis I, Diels S, Van Ham L (2010). Clinical and electrophysiological characterisation of generalized myokymia and neuromyotonia in Jack Russell Terriers: a. Journal of Veterinary Internal Medicine 24, 91-97.
Vanhaesebrouck A, Couturier J, Cauzinille L, Mizisin A, Shelton D, Granger N (2008). Demyelinating polyneuropathy with focally folded myelin sheaths in a family of Miniature Schnauzer dogs. Journal of the Neurological Sciences 275, 100-105.
