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Genetics Study

Genetic Study 


The aim of the genetic study is to find the association between the phenotype (BOAS) and the genotype (specific alteration in DNA and the encoded proteins) underlying the respiratory function in brachycephalic dogs. Using a non-invasive sampling method (buccal swabs), we are building a DNA bank of brachycephalic dogs with known BOAS status (using both WBBP and clinical reports).

We have started to process the samples (more than 700 samples have been collected so far) to find genetic differences (loci implicated in the disease) between affected and non-affected groups by genome wide association studies (GWAS). After identifying the genetic regions that are responsible for increasing the risk of BOAS, we will use bioinformatics (gene localization, functional characterization) and genetic methods (direct sequencing) to reveal the molecular mechanisms behind the disease.  

DNA sample collection
DNA sample collection via cheek swabs
Preparing samples for PCR
Preparing samples for PCR











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Crufts 2017

The BOAS group was delighted to welcome the Channel 4 team that is covering Crufts to film a short segment on airway disease in the brachycephalic dogs. Iwan Thomas brought his delightful young French bulldog puppy, Frank who was star of the show…..

Plagues edited by Jonathan Heeney & Sven Friedemann - Published by CUP

Plagues have inflicted misery and suffering throughout history. This book examines the spectrum of tragic consequences of different types of plagues, from infectious diseases to over-population and computer viruses. The essays analyse the impact that plagues have had on humanity and animals.


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