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Department of Veterinary Medicine

Cambridge Veterinary School

Studying at Cambridge

 

Dr AW (Dan) Tucker

Dr AW (Dan) Tucker

Senior Lecturer in Veterinary Public Health

AW (Dan) Tucker is interested in taking PhD students.


Office Phone: +44 (0)1223 330885

Subject groups/Research projects

Infection and Immunity:

Departments and Institutes

Cambridge Infectious Diseases:

Research Interests

My research interests lie in the control of infectious diseases that threaten food chain security. These threats to food security include animal-to-human infections (zoonoses), over-reliance on antimicrobial drugs, reduced feed conversion efficiency, and compromised welfare. I try to combine my clinical interest in intensive pig production with multidisciplinary research that includes molecular and epidemiological approaches aiming towards better prevention and management of infectious disease. My current research is focused on application of new molecular technologies to entrenched endemic diseases of pigs. This includes whole genome sequencing studies of bacterial respiratory pathogens of pigs to identify new diagnostic and epidemiological tools (Streptococcus suis, Haemophilus parasuis, Actinobacillus pleuropneumoniae, and Mycoplasma hyopneumoniae). We are using a functional genomics method, transposon directed insertion site sequencing (TraDIS), and ex vivo respiratory organ culture systems to identify genes in S. suis and H. parasuis worthy of future investigation as vaccine candidates.

Through a Junior / Senior Clinical Training Scholarship Program (funded by Pfizer Animal Health) we also participate in a variety of applied clinical research projects involving representatives of the local pig industry.

Main collaborators

  • Duncan Maskell, Department of Veterinary Medicine, University of Cambridge
  • James Wood, Department of Veterinary Medicine, University of Cambridge
  • Paul Langford, Imperial College, London
  • Andrew Rycroft, Royal Veterinary College, London
  • Brendan Wren, London School of Hygiene and Tropical Medicine, London
  • Rui Zhou, Huazhong Agricultural University, Wuhan, China

Keywords

  • Infection
  • Food chain security
  • Epidemiology
  • Zoonoses
  • articular chondrocytes

Key Publications

  • Jäger HJ, McKinley TJ, Wood JLN, Pearce GP, Williamson S, Strugnell B, Done S, Habernoll H, Palzer A, Tucker AW. 2012. Factors associated with pleurisy in pigs: A case-control analysis of slaughter pig data for England and Wales. Accepted for publication, PLoS One.
  • Pal N, Baker R, Schalk S, Scobie L, Tucker AW, Opriessnig T. 2011. Detection of porcine endogenous retrovirus (PERV) viremia in diseased versus healthy US pigs by qualitative and quantitative real-time RT-PCR. Transbound Emerg Dis. 58(4):344-51. [PubMed]
  • Wilkinson JM, CA Sargent, L Galina-Pantoja, AW Tucker. Gene expression profiling in the lungs of pigs with different susceptibilities to Glasser's disease. BMC Genomics. 2010; 11: 455-462. [PubMed]
  • Lucianez A, Holmes MA, Tucker AW. Relationships between processing delay and microbial load on broiler neck skin samples. Journal of Food Protection. 2010; 73:26-31. [PubMed]
  • Donadeu M, Siebert K, Tucker AW. Eradication of enzootic pneumonia from a pig unit without partial depopulation using a method selected by calculating expected project value. The Pig Journal. 2010; 63: 5-9.
  • Niesalla H., Dale A., Scholes S., Slater J., Maskell D., Tucker A. Critical assessment of an in vitro bovine respiratory organ culture system: a model of bovine herpesvirus-1 infection. Journal of Virological Methods. 2009; 158:123-129 [PubMed]
  • Nunes F, Murcia P, Tiley LS, Brown IH, Tucker AW, Maskell DJ and Wood JLN. An ex vivo swine tracheal organ culture for the study of influenza infection. Journal of Influenza and other respiratory viruses. Influenza and Other Respiratory Viruses. 2009; 4: 7-15.
  • Grierson SS, King DP, Tucker AW, Donadeu M, Mellencamp MA, Haverson K, Banks M, Bailey M. (2007). Ontogeny of systemic cellular immunity in the neonatal pig: Correlation with the development of post-weaning multisystemic wasting syndrome. Vet Immunol Immunopathol. 119. 254-268. [PubMed]
  • de la Fuente AJ, Tucker AW, Navas J, Blanco M, Morris SJ, Butierrez-Martin CB. Antimicrobial susceptibility patterns of Haemophilus parasuis from pigs in the United Kingdom and Spain. Vet Microbiol. 2007. Feb 25; 120 (1-2): 184-91. [PubMed]