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Department of Veterinary Medicine

Cambridge Veterinary School

Studying at Cambridge

 

Dr Caroline Trotter

Dr Caroline  Trotter

Senior Lecturer in Epidemiology

Epidemiology and Mathematical Modelling


Office Phone: +44 1223 765631

Biography:

I am an infectious disease epidemiologist, based in the Disease Dynamics Unit. I obtained my first degree in Human Sciences from the University of Oxford before completing an MSc in Communicable Disease Epidemiology at the London School of Hygiene and Tropical Medicine. My PhD (University of London, 2004), based jointly at LSHTM and the Health Protection Agency, examined the impact of vaccination against group C meningococcal (MenC) disease. I spent 7 years at the University of Bristol before moving to Cambridge in 2013.

Subject groups/Research projects

Mathematical Biology:

Research Interests

My research concentrates on understanding the epidemiology of vaccine-preventable diseases and the impact of immunisation. The majority of my work is on meningococcal infection, but I am also involved in research on pneumococcus, rotavirus, group B streptococcus and human papillomavirus. I use a range of methods including analysis of large databases, systematic reviews, prospective clinical/ field studies, health economics, seroprevalence studies and mathematical modelling. I am most interested in applying these methods to research questions of direct relevance for vaccine policy.

I currently work with the African Meningococcal Carriage Consortium (MenAfriCar), a global research effort to study how meningococcal meningitis is spread in Africa, and to document the impact of a new meningitis vaccine (MenAfriVac) on reducing transmission. Our recent study in Chad has shown that MenAfriVac has had a dramatic impact on disease and carriage in a region experiencing a group A epidemic.

I also work on collaborative projects with Public Health England, University of Bristol, SGULMeningitis Vaccine Project and the World Health Organisation

Research Supervision

I co-supervise 2 PhD students at the University of Bristol:

  • Harriet Fisher, "Examination of the uptake of the human papillomavirus vaccination programme and its impact on health inequalities", with Matthew Hickman and Suzanne Audrey
  • Robin Marlow, "Epidemiology, costs & control of viral gastroenteritis in children in hospital", with Adam Finn

Hannah Christensen, Tom Irving and Emily Nicoli completed their PhDs at the University of Bristol in 2011, 2013 and 2014 respectively.

Keywords

  • Mathematical modelling
  • Epidemic control
  • Vaccines
  • Epidemiology
  • Bacterial meningitis
  • Infectious Diseases

Collaborators

Key Publications

For a full list click here

Daugla DM, Gami JP,  Gamougam K, Naibei N, Mbainadji L, Narbé M,  Toralta J, Kodbesse B, Ngadoua C, Coldiron M, Ferman F, Page A-L,  Djingarey M,  Hugonnet S, Harrison OB, Rebbetts LS, Tekletsion Y, Watkins ER, Caugant DA,  Chandramohan D,  Hassan-King M, Manigart O, Nascimento M, Woukeu A,  Trotter C, Stuart JM, Maiden MCJ, Greenwood B. The impact of a serogroup A meningococcal conjugate vaccine (PsA-TT) on serogroup A meningococcal meningitis and carriage in Chad. Lancet 2014.383:40-7

Christensen H, Hickman M, Edmunds WJ, Trotter CL. Introducing vaccination against serogroup B meningococcal disease: an economic and mathematical modelling study of potential impact. Vaccine 2013;31(23):2638-46

Irving T, Blyuss K, Colijn C, Trotter CL. Modelling meningococcal meningitis in the African meningitis belt. Epidemiol & Infect 2012 May;140(5):897-905.

Rozenbaum M, van Hoek AJ, Fleming D, Trotter CL, Miller E, Edmunds WJ. Cost-effectiveness of vaccinating risk groups in England against invasive pneumococcal disease using the 13 valent pneumococcal vaccine: an economic analysis. BMJ. 2012 345:e6879

Christensen H, May MT, Bowen L, Hickman M, Trotter CL. A systematic review of meningococcal carriage by age. Lancet Infect Dis 2010, 10:853-61

Harrison LH, Trotter CL, Ramsay ME. Global epidemiology of meningococcal disease. Vaccine. 2009. 27(S2):B51-B63.

Trotter CL, McVernon J, Ramsay ME, Whitney CG, Mulholland K, Goldblatt D, Hombach J, Kieny M-P, on behalf of the SAGE subgroup.. Optimising the use of conjugate vaccines for Haemophilus influenzae type b, Neisseria meningitidis and Streptococcus pneumoniae. Vaccine. 2008, 26(35):4434-45.

Trotter CL, Greenwood BM. Meningococcal carriage studies in the African meningitis belt: a review. Lancet Infect Dis. 2007; 7(12): 797-803