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Department of Veterinary Medicine

Cambridge Veterinary School

Studying at Cambridge

 

Dr Kate Hughes

Dr Kate Hughes

Lecturer in Veterinary Pathology

Kate Hughes is accepting applications for PhD students.

Kate Hughes is available for consultancy.


Biography:

Kate undertook her veterinary training at the University of Liverpool. During her veterinary degree she intercalated in Anatomy and Human Biology and was awarded a first class BSc (Hons). She was a fellow of the Cornell Leadership Program for Veterinary Students in 2001. She graduated as a veterinary surgeon with a BVSc awarded with distinction. Following graduation, Kate worked as a clinical veterinarian prior to undertaking a Senior Clinical Training Scholarship (residency) in Veterinary Anatomic Pathology at the University of Cambridge. After her postgraduate Veterinary Anatomic Pathology training, she secured a Wellcome Trust Research Training Fellowship to study for a PhD in the laboratory of Christine Watson in the Department of Pathology, Cambridge. Following her PhD, she remained in the Watson Laboratory to pursue post-doctoral studies. She has now returned to the Veterinary School and holds a University Lectureship in Veterinary Pathology and an Official Fellowship at Girton College. Kate is a Fellow of the Royal College of Pathologists and a Diplomate of the American College of Veterinary Pathologists.

 

Prizes, honours and awards:

2012 Royal College of Pathologists Gold Medal for Trainees in Research.

2015 Zoetis Clinical Research Award.

Research Interests

Kate studies the mammary gland and tumours developing in this tissue. Her particular field of interest encompasses the interactions between different cell types within the mammary gland during regression at the end of lactation (mammary gland involution). As a veterinary pathologist, and active diagnostician, she also has wider interests in diagnostic veterinary pathology. She is particularly interested in companion animal neoplasia, especially mammary tumours arising in pet dogs and cats.

Keywords

  • Molecular Biology
  • Mammary involution
  • Veterinary pathology
  • Mammary glands
  • Macrophage

Key Publications

  1. Kucia-Tran J, Tulkki V, Smith S, Scarpini C, Hughes K, Araujo A, Yan K, Botthof J, Pérez-Gómez E, Quintanilla M, Cuschieri K, Munoz-Caffarel M, Coleman N. Over-expression of the oncostatin-M receptor in cervical squamous cell carcinoma is associated with epithelial-mesenchymal transition and increased metastasis. Br J Cancer. 2016; Advance online publication, doi:10.1038/bjc.2016.199
  2. Malcolm T, Villarese P, Fairbairn C, Lamant L, Trinquand A, Hook C, Amos Burke G, Brugières L, Hughes K, Payet D, Merkel O, Schiefer A, Ashankyty I, Mian S, Wasik M, Turner M, Kenner L, Asnafi V, Macintyre E, Turner SD. Anaplastic large cell lymphoma arises in thymocytes and requires transient T cell receptor expression for thymic egress. Nat Commun. 2016; 7, article number: 10087.
  3. Hughes K, Archer J, Constantino-Casas F, Wozniakowski G, Baigent S. Diagnostic investigation of Marek’s disease in a turkey. Vet Rec Case Rep. 2016; 4, article number: 00291.
  4. Scott VHL, Hughes KDiagnosis of equine penile and preputial masses: A clinical and pathological perspective. Equine Veterinary Education. 2015; In press. doi: 10.1111/eve.12476
  5. Hughes K, Scase TJ, Foote, AK. Estrogen receptor and Signal Transducer and Activator of Transcription 3 expression in equine mammary tumors. Vet Path. 2015; 52 (4)631-634. doi:10.1177/030098581455940
  6. Man SM, Ekpenyong A, Tourlomousis P, Achouri S, Cammarota E, Hughes K, Rizzo A, Ng G, Wright JA, Cicuta P, Guck JR, Bryant CE. Actin polymerization as a key innate immune effector mechanism to control Salmonella infection. Proc Natl Acad Sci USA. 2014; 111 (49): 17588-93. doi: 10.1073/pnas.1419925111.
  7. Watson C, Hughes K. Breast cancer: the menacing face of Janus kinase. Cell Death Differ. 2014; 21 (2): 185-6. doi: 10.1038/cdd.2013.170.
  8. Hughes K, Wickenden J, Allen J, Watson C. Conditional deletion of Stat3 in mammary epithelium impairs the acute phase response and modulates immune cell numbers during post-lactational regression. J Pathol. 2012; 227 (1): 106–117. doi: 10.1002/path.3961
  9. Hughes K, Dobson J. Prognostic histopathological and molecular markers in feline mammary neoplasia. The Veterinary Journal. 2012; 194 (1):19-26. doi: 10.1016/j.tvjl.2012.05.008.
  10. Hughes K, Watson C. The spectrum of Stat functions in mammary gland development. JAK-STAT. 2012; 1 (3): 151–158. http://dx.doi.org/10.4161/jkst.19691
  11. Hughes K, Watson C. The role of Stat3 in mammary gland involution: Cell death regulator and modulator of inflammation. Horm Mol Biol Clin Invest. 2012; 10 (1): 211–215. doi: 10.1515/hmbci-2012-0008
  12. Scase T, Brandt S, Kainzbauer C, Sykora S, Bijmholt S, Hughes K, Sharpe S, Foote A. Equus caballus papillomavirus-2 (EcPV-2): an infectious cause for equine genital cancer? Equine Vet J. 2010; 42(8): 738-45.
  13. Talbot S, Tötemeyer S, Yamamoto M, Akira S, Hughes K, Gray D, Barr T, Mastroeni P, Maskell DJ, Bryant CE. Toll-like receptor 4 signalling through MyD88 is essential to control Salmonella enterica serovar typhimurium infection, but not for the initiation of bacterial clearance. Immunology. 2009; 128 (4): 472-83.
  14. Harcourt-Brown TR, Granger N, Smith PM, Hughes K, Jeffery ND. Use of a lateral surgical approach to the femoral nerve in the management of two primary femoral nerve sheath tumours. Vet Comp Orthop Traumatol. 2009; 22 (3): 229-32.
  15. Hughes K, Scase TJ, Ward C, Polton GA. Vincristine overdose in a cat: clinical management, use of calcium folinate, and pathological lesions. J Feline Med Surg. 2009; 11 (4): 322-5.
  16. Hughes K, Mueller K. Pathologic lesions of mycotic pneumonia in an alpaca following third compartment ulceration. J Vet Diagn Invest. 2008; 20 (5): 672-5.