Reader in Comparative Oncology and Genetics
Subject groups/Research projects
- Genetics and Oncology:
Transmissible cancers in dogs and Tasmanian devils
Our lab works on the genetics and evolution of transmissible cancers. There are only two known naturally occurring clonally transmissible cancers and these are the Tasmanian devil facial tumour disease (DFTD) and the canine transmissible venereal tumour (CTVT). These two cancers are transmitted between individuals by the transfer of living cancer cells. DFTD is transmitted between Tasmanian devils by biting and CTVT is spread between dogs during coitus. DFTD is threatening its host, the Tasmanian devil, with extinction. We use genetics, genomics and molecular biology to understand the origins, evolution and disease dynamics of the DFTD and CTVT clones. We also study genetic factors influencing host susceptibility, disease pathogenesis and treatment responses. We aim to understand how DFTD and CTVT have emerged and adapted to their hosts with the goal of developing DFTD and CTVT treatment options and using transmissible cancers to gain general insights into cancer evolution.
Elizabeth Murchison’s TED talk entitled "Fighting a contagious cancer"
Prizes, Honours and Awards
- Genetics Society Balfour Prize Lecture, 2014
- Eppendorf Young Investigator Award, 2012
- MRC Jewellery Heirloom Award, 2012
- L’Oreal-UNESCO For Women in Science Fellowship, 2009
Murchison EP, Wedge DC, Alexandrov LB, Fu, B, Martincorena I, Ning Z, Tubio JMC, Werner EI, Allen J, Barboza de Nardi A, Donelan EM, Marino G, Fassati A, Campbell PJ, Yang F, Burt A, Weiss RA, Stratton MR (2014) Transmissible dog cancer genome reveals the origin and history of an ancient cell lineage. Science. Jan 24;343(6169):437-40
Murchison EP, Schulz-Trieglaff OB, Ning Z, Alexandrov LB, Bauer MJ, Fu B, Hims M, Ding Z, Ivakhno S, Stewart C, Ng BL, Wong W, Aken B, Alsop A, Becq J, Bignell GR, Cheetham RK, Cheng W, Connor TR, Cox AJ, Feng Z, Gu Y, Grocock RJ, Harris SR, Khrebtukova I, Kingsbury Z, Kowarsky M, Kreiss A, Luo S, Marshall J, McBride DJ, Murray L, Pearse AM, Raine K, Rasolonjatovo I, Shaw R, Tedder P, Tregidgo C, White S, Woods GM, Gormley N, Humphray S, Schroth G, Smith G, Hall K, Searle S, Carter N, Papenfuss AT, Futreal PA, Campbell P, Yang F, Bentley DR, Evers DJ and Stratton MR (2012) Genome sequencing and analysis of the Tasmanian devil and its transmissible cancer. Cell. Feb 17;148(4):780-91
Bender HS, Murchison EP, Pickett HA, Deakin JE, Strong MA, Conlan C, McMillan DA, Neumann AA, Greider CW, Hannon GJ, Reddel RR and Graves JAM (2012) Extreme telomere length dimorphism in the Tasmanian devil and related marsupials suggests parental control of telomere length. PLoS ONE 7(9):e46195
Greenlee AR, Shiao M-S, Snyder E, Buaas FW, Gu T, Stearns TM, Sharma M, Murchison EP, Puente GC and Braun RE (2012) Deregulated sex chromosome gene expression with male germ cell-specific loss of Dicer1. PLoS ONE 7(10): e46359
Nilsson Janke MA, Janke A, Murchison EP, Ning Z and Hallström BM (2012) Expansion of CORE-SINEs in the genome of the Tasmanian devil. BMC Genomics. May 6;13(1):172
Deakin JE, Bender HS, Pearse AM, Rens W, O’Brien PC, Ferguson-Smith MA, Cheng Y, Morris K, Taylor R, Stuart A, Belov K, Amemiya CT, Murchison EP, Papenfuss AT and Graves JA (2012) Genomic restructuring in the Tasmanian devil facial tumour: chromosome painting and gene mapping provide clues to evolution of a clonally transmissible tumour. PLoS Genetics Feb;8(2):e1002483. Epub 2012 Feb 16.
Lee S, Paulson KG, Murchison EP, Afanasiev OK, Alkan C, Leonard JH, Byrd DR, Hannon GJ, Nghiem P (2011) Identification and validation of a novel mature microRNA encoded by the Merkel cell polyomavirus in human Merkel cell carcinomas. J. Clin. Virol. doi:10.1016/j.jcv.2011.08.012
Murchison EP and Adams DJ (2011) Sequencing Skippy: The genome of an Australian kangaroo Macropus eugenii. Genome Biology. 12:123
Spierings DC, McGoldrick D, Hamilton-Easton AM, Neale G, Murchison EP, Hannon GJ, Green DR, Withoff S. (2011) Ordered progression of stage-specific miRNA profiles in the mouse B2 B-cell lineage. Blood 177(20):5340-9
Tovar C, Obendorf D, Murchison EP, Papenfuss AT, Kreiss A and Woods GM (2011) A tumor-specific diagnostic marker for transmissible facial tumors of Tasmanian devils: immunohistochemistry studies. Veterinary Pathology Online. 48(6),1195-1203
Murchison EP, Tovar C, Hsu A, Bender HS, Kheradpour P, Rebbeck C, Obendorf D, Conlan C, Bahlo M, Blizzard C, Pyecroft S, Kreiss A, Kellis M, Stark A, Harkins TT, Graves JAM, Woods GM, Hannon GJ and Papenfuss AT (2010) The Tasmanian devil transcriptome reveals Schwann cell origins of a clonally transmissible cancer. Science. Jan 1 327(5961):84-7
Murchison EP (2009) Clonally transmissible cancers in dogs and Tasmanian devils. Oncogene 27: S19 – S30.