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Department of Veterinary Medicine

Cambridge Veterinary School

Studying at Cambridge

 

Alphonsus Chinedu Ugwu

Alphonsus Chinedu Ugwu

Title: Host and viral factors that aid the non-pathogenic interaction of the bat immune system with RNA viruses

Supervisor: Prof Jonathan Heeney


Biography:

I obtained my Doctor of Veterinary Medicine degree (DVM) from the University of Ibadan in 2010. After one year national service at the veterinary teaching hospital university of Abuja, I received a Presidential Scholarship for Innovation and Development (PRESSID) from the Federal Government of Nigeria to undertake postgraduate studies in any of the top twenty five universities in the world. With this I have just completed an MSc in Integrated Immunology at the University of Oxford and now I am currently doing a PhD in Veterinary Science at the University of Cambridge. My research aims to Understand the fine balance of RNA virus interactions with antigen presenting cells (dendritic cells) in reservoir species such as bats and non human primates.

Subject groups/Research projects

Infection and Immunity:

Research Interests

Bats are reservoirs of a number of RNA viruses which causes no clinical disease in them but are capable of causing catastrophic human disease when these viruses spillover to disease susceptible species such as humans or great apes. Many of these viruses replicate in dendritic cell which are professional antigen presenting cell that link innate and adaptive arms of the immune system. My interest is in understanding the host and viral factors that aid the non-pathogenic interaction of the bat immune system with RNA viruses such that a balance exists without deleterious outcome as seen in humans. Understanding these finely controlled host-viral interactions may provide therapeutic avenues to treat susceptible species.

Keywords

  • Dendritic cells
  • Non human primates
  • Bats
  • RNA virus