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Department of Veterinary Medicine

Cambridge Veterinary School

Studying at Cambridge

 

Dr Craig Hughes

Dr Craig Hughes

Research Associate


Biography:

2007-2010: BSc Biological science (2.1) Biology , Universiy of Essex, UK

2010-2014: PhD in cell and molecular biology. Thesis title: Real time single molecule investigation of the dynamics of nucleotide excision repair proteins on DNA tightropes.

Subject groups/Research projects

Infection and Immunity:

Research Interests

The molecular basis of the innate response to oligomers of beta amyloid and alpha synuclein

The focus of my research is the innate immune responses to oligomers of beta amyloid and alpha synuclein. These proteins are linked to the development of both alzheimer's disease and parkinson's disease. I am interested in why the body’s immune response can switch from being protective against these diseases to being destructive, helping to damage cells.

Keywords

  • repair
  • s synuclein
  • Neurodegeneration
  • Single molecule

Collaborators

Collaborators outside this directory

Key Publications

Hughes, C.D., Wang, H., Ghodke, H., Simons, M., Towheed, M.A., Peng, Y., Van Houten, B., Kad, N.M. 2013. Real time single molecule imaging reveals a direct interaction between UvrC and UvrB on DNA tightropes. Nucleic Acids Research, 41, 4901-4912. Impact factor 8.026


Hughes, C.D., Simons, M., Mackenzie, C.E,. Van Houten, B., Kad, N, M. 2014. Single molecule techniques in DNA repair: A primer. DNA Repair, 20, 2-13. Impact factor 3.362