Supervisor - Dr Mark Holmes
Iron acquisition of S.aureus CC130 isolates
1st Year PhD student working on MRSA with Dr Mark Holmes and Dr Gavin Patterson at the Department of Veterinary Medicine. My current area of research is looking at Iron acquisition in S.aureus CC130 isolates. Previously worked as an Advanced Research Assistant for Professor Gordon Microbial Pathogenesis group at the Wellcome Trust Sanger Institute.
Subject groups/Research projects
The role of sphingosine-1-phosphate transporter Spns2 in immune system function.
Nijnik A, Clare S, Hale C, Chen J, Raisen C, Mottram L, Lucas M, Estabel J, Ryder E, Adissu H; Sanger Mouse Genetics Project, Adams NC, Ramirez-Solis R, White JK, Steel KP, Dougan G, Hancock RE.
J Immunol. 2012 Jul 1;189(1):102-11.
Use of purified Clostridium difficile spores to facilitate evaluation of health care disinfection regimens.
Lawley TD. Clare S. Deakin LJ. Goulding D, Yen JL, Raisen C, Brandt C, Lovell J, Cooke F, Clark TG, Dougan G. Appl Environ Microbiol 2010 Oct; 76(20):6895-900
Antibiotic treatments of Clostridium difficile carrier mice triggers a supershedder state, spore-mediated transmission, and severe disease in immunocompromised hosts.
Lawley TD, Clare S, Walker AW, Goulding D, Stabler RA, Croucher N, Mastroeni P, Scott P, Raisen C, Mottram L, Fairweather NF, Wren BW, Parkhill J, Dougan G. Infect Immu 2009 Sep; 77(9):3661-9
The Critical Role of Histone H2A-deubiquitinase Mysm1 in Haematopoiesis and Lymphocyte Differentiation.
Nijnik A, Clare S, Hale C, Raisen C, McIntyre RE, Yusa K, Everitt AR, Mottram L, Podrini C, Lucas M, Estabel J, Goulding D; Sanger Institute Microarray Facility; Sanger Mouse Genetics Project, Adams N, Ramirez-Solis R, White JK, Adams DJ, Hancock RE, Dougan G.
Blood. 2012 Feb 9;119(6):1370-9.
Targeted restoration of the intestinal microbiota with a simple, defined bacteriotherapy resolves relapsing Clostridium difficile disease in mice.
TD. Lawley, S Clare, AW. Walker, MD. Stares, Connor TR, C Raisen, D Goulding, R Rad, F Schreiber, C Brandt, LJ. Deakin, DJ. Pickard, SH. Duncan, HJ. Flint, TG. Clark, J Parkhill, G Dougan. PLoS Pathog 2012 Oct; 8(10):e1002995.