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Dr Frances Henson MA, VetMB, PhD, Cert ES, Cert EM, RCVS Specialist in Equine Surgery

Dr Frances Henson, MA, VetMB, PhD, Cert ES, Cert EM, RCVS Specialist in Equine Surgery

Senior Lecturer in Equine Surgery, Department of Veterinary Medicine,

Research Fellow Division of Trauma and Orthopaedic Surgery, Department of Surgery, Addensbrooke's Hospital, Cambridge

Frances Henson is interested in taking PhD students.

Frances Henson is available for consultancy.


Subject groups/Research projects

Comparative Pathobiology:

Orthopaedic disease -cartilage and bone biology, joint repair, translational medicine, stem cells

Research Interests

I am interested in the pathophysiology of bone and joint disease and repair. I am a Research Fellow in the division of Trauma and Orthopaedic Surgery, Department of Surgery, Addenbrooke’s Hospital, Cambridge where I work with Professor Andrew McCaskie in addition to providing a clinical orthopaedic service for equine patients at the Cambridge Equine Hospital.

My particular areas of active research interest at the current time include the use of biosynthetic scaffolds, cells and biological factors to repair mensical, osteochondral and chondral defects (with Prof. McCaskie, Dr Wardale and Dr Howard), the response of cartilage to load (with particular emphasis on the response of the serine protease HtrA1) (with Dr Paula Hernandez),the role of the wnt signalling pathway inhibitor, sclerostin, in osteochondral repair (with Dr Wardale and Dr Hyvonen) and the aetiopathogenesis of stress fractures in racing horses (with Drs Power and Singer).

 

Main collaborators:

  • Professor Andrew McCaskie, Department of Surgery, University of Cambridge
  • Dr John Wardale, Department of Surgery, University of Cambridge
  • Dr Marko Hyvonen, Department of Biochemistry, University of Cambridge
  • Dr Alan Getgood, Fowler Kennedy Sports Medicine Institue, Ontario, Canada, Assistant Prof. University Western Ontario
  • Dr John Power, University of Chester
  • Dr Ellen Singer, University of Liverpool
  • Dr Dan Howard, Department of Haematology, University of Cambridge

My work is currently funded by the UK Regenerative Medicine Platform (UKRMP), the HorseRace Betting Levy Board (HBLB) Fund and Merck Serono.

Keywords

  • Osteochondral defects
  • Biosynthetic scaffolds
  • Ageing
  • Stem cells
  • cellular pathophysiology
  • Pathology
  • articular chondrocytes

Key Publications

Full list of publications at https://www.researchgate.net/profile/Frances_Henson/contributions/?ev=prf_act
Selected recent publications:
  • Howard D, Wardale J, GuehringMD H, Henson FMD(2015) Delivering rhFGF-18 via a bilayer collagen membrane to enhance microfracture treatment of chondral defects in a large animal model. J Orthop Res doi: 10.1002/jor.22882
  • Hopper, N., Wardale, R., Howard, D., Brooks, R., Rushton N. and Henson FMD (2015) Peripheral derived mononuclear cells enhance the migration and chondrogenic differentiation of multi potent mesenchymal stromal cells. Stem Cell Int. doi: 10.1155/2015/323454
  • Barr L, Getgood A, Guehring H, Rushton N, Henson FMD (2014) The effect of recombinant human fibroblast growth factor-18 on articular cartilage following single impact load. J Orthop Res. 2014 Jul;32(7):923-7. 
  • Power, J., Hernandez P., Guering H., Getgood A. and Henson FMD (2014) Intra-articular injection of rhFGF-18 improves the healing in microfracture treated chondral defects in an ovine model. J Orthop Res. 32(5) 669-676. 
  • Getgood, A., Henson, FMD., Skelton, C., Herrera, E., Brooks, R., Fortier, L. A., and Rushton, N. (2012). The Augmentation of a Collagen/Glycosaminoglycan Biphasic Osteochondral Scaffold with Platelet-Rich Plasma and Concentrated Bone Marrow Aspirate for Osteochondral Defect Repair in Sheep: A Pilot Study. Cartilage, 3(4), 351-363.
  • Henson, F. M., Getgood, A. M., Caborn, D. M., McIlwraith, C. W., & Rushton, N. (2012). Effect of a solution of hyaluronic acid-chondroitin sulfate-N-acetyl glucosamine on the repair response of cartilage to single-impact load damage.. Am J Vet Res, 73(2), 306-312. 
  • Enea D, Henson F M, Kew S, Wardale J, Getgood A, Brooks R, Rushton N. (2011) Extruded collagen fibres for tissue engineering applications: effect of crosslinking method on mechanical and biological properties. J. Mater. Sci: Mater Med 22(6): 1569-78.
  • Getgood A, Henson F M, Brooks R, Fortier LA, Rushton N. (2011) Platelet-rich plasma activation in combination with biphasic osteochondral scaffolds- conditions for maximal growth factor production.Knee Surg Sports Traumatol Arthrosc. 19 (11): 1942-7.