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Department of Veterinary Medicine

Cambridge Veterinary School

Studying at Cambridge

 

Dr Ilias Kazanis

Dr Ilias Kazanis

Senior Research Associate in Neurosciences


Office Phone: +44 1223 765048

Biography:

2005-2011: Research associate, Department of Pathology, University of Cambridge, UK.

2002-2003: Research associate, Mammalian neurogenesis group, MRC Clinical Sciences Centre, London, UK.

2002, PhD in Neuroptahology (thesis on experimental brain injury), Medical School, University of Athens, Greece.

1997, Bachelor in Biology, University of Patras, Greece.

Subject groups/Research projects

Neurosciences:

The biology of adult brain neural stem cells

Research Interests

My research focuses on neural stem cell-driven cytogenesis in the adult brain and more specifically on the activity of the subependymal zone neurogenic/gliogenic niche. I have investigated the structural features of the niche (extracellular matrix, ependymal cells and the cerebrospinal fluid, blood vessels) in respect to the regulation of adult neural stem cell behaviour. How is the niche microenvironment altered when stem cells become activated in order to regenerate the neural tissue? How has the structure of the niche changed during evolution? Recently I have started exploring more intensively the oligodendrogenic properties of the subependymal zone, especially in the context of the ageing brain and of demyelinating diseases, as well as the potential to develop new methods to isolate neural progenitors from the niche.

Keywords

  • Oligodendrocyte precursor cells (OPCs)
  • Neurodegeneration
  • Myelination
  • Ageing
  • Remyelination
  • Stem cells
  • Multiple Sclerosis
  • Adult stem cells

Collaborators

Collaborators outside this directory

Key Publications

Kazanis I, Gorenkova N, Zhao JW, Franklin RJ, Modo M, Ffrench-Constant C (2013), "The late response of rat subependymal zone stem and progenitor cells to stroke is restricted to directly affected areas of their niche." Exp Neurol 248:387-97

Kazanis I, Ffrench-Constant C (2012), “The number of stem cells in the subependymal zone of the adult rodent brain is correlated with the number of ependymal cells and not with the volume of the niche.” Stem Cells Dev 21(7):1090-6

Kazanis I, Lathia JD, Vadakkan TJ, Raborn E, Wan R, Mughal MR, Eckley DM, Sasaki T, Patton B, Mattson MP, Hirschi KK, Dickinson ME, ffrench-Constant C (2010), “Quiescence and activation of stem and precursor cell populations in the subependymal zone of the mammalian brain are associated with distinct cellular and extracellular matrix signals.” J Neurosci 30(29):9771-81.

Kazanis I (2009), “The subependymal zone neurogenic niche: a beating heart in the centre of the brain: how plastic is adult neurogenesis? Opportunities for therapy and questions to be addressed.” Brain 132(Pt 11):2909-21

Kazanis I, Belhadi A, Faissner A, Ffrench-Constant C (2007), “The adult mouse subependymal zone regenerates efficiently in the absence of tenascin-C.” J Neurosci 27(51):13991-6.

Ekonomou A, Kazanis I, Malas S, Wood H, Alifragis P, Denaxa M, Karagogeos D, Constanti A, Lovell-Badge R, Episkopou V (2005), “Neuronal migration and ventral subtype identity in the telencephalon depend on SOX1.” PLoS Biol 3(6):e186.