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Department of Veterinary Medicine

Cambridge Veterinary School

Studying at Cambridge

 

Dr Laura Peachey

Dr Laura Peachey

Research Associate


Biography:

I am a veterinary surgeon with a keen interest in parasitology research. I qualified in veterinary science from the University of Liverpool in 2007, having intercalated with a BSc in veterinary pathology at the Royal Veterinary College in 2005. Following my veterinary degree I did a clinical internship in equine medicine and surgery at the University of Liverpool followed by a short research project investigating an outbreak of cerebral trypanosomiasis in equids in the Gambia. I Accepted a research assistant post at the University of Liverpool in 2010 evaluating the potential of bioactive plant compounds to treat equid gastrointestinal (GI) nematodes in Ethiopia. I then performed a PhD focusing on anthelmintic resistance mechanisms and alternative control methods in equid GI nematodes, graduating in 2016. Following this I was awarded a fellowship from the Horserace Betting Levy Board to continue my research investigating host-parasite-microbiota interactions in equid GI nematodes at the University of Cambridge.

Subject groups/Research projects

Infection and Immunity:

Research Interests

During my PhD I focused on investigating alternative control methods for gastrointestinal (GI) nematodes in equids in the face of multidrug resistant infections. This work ranged from identifying bioactive plant compounds with anthelmintic activity, to evaluating the potential of multidrug resistance transporter inhibitors to improve antelmintic efficacy in drug resistant equid nematodes. The work was centred around the use of in vitro bioassays to measure anthelmintic effects. During my fellowship at Cambridge, I aim to look more deeply into host-parasite interactions in equid GI nematode infections and use this information to inform novel intervention strategies aimed at reducing the heavy reliance on chemotherapy to treat these parasites. Specifically I am interested in associations between the GI microbiota, GI nematodes and host transcriptional responses. I will be using next-generation sequencing and bioinformatics tools to explore these interactions.

Keywords

  • Host-pathogen interaction
  • Microbiome
  • Anthelmintic resistance
  • Gastrointestinal nematodes

Collaborators

Key Publications

Peachey L.E., Pinchbeck G.L., Matthews J.B., Burden F.A., Behnke J.M., Hodgkinson J.E. (2016). Papaya latex supernatant has a potent effect on the free living stages of equid cyathostomins in vitro. Veterinary Parasitology 228: 23-29.

Peachey, L.E., Pinchbeck, G.L., Matthews, J.B., Burden, F.A., Mulugeta, G., Scantlebury, C.E., Hodgkinson, J.E (2015). An evidence-based approach to the evaluation of ethnoveterinary medicines against strongyle nematodes of equids. Veterinary Parasitology 210: 40-52.

Peachey L., Matthews J., Pinchbeck G., Behnke J., Burden F., Hodgkinson, J. A potential Novel Anthelmintic? The cysteine proteases show potent anthelmintic activity against cyathostomins in vitro. Equine Veterinary Journal 46:23-23. (Conference abstract)

Scantlebury C.E., Peachey L., Hodgkinson J., Matthews J.B., Trawford A., Mulugeta G., Tefera G., Pinchbeck G.L. (2013). Participatory study of medicinal plants used in the control of gastrointestinal parasites in donkeys in Eastern Shew and Arsi zones of Oromia region, Ethiopia. BMC Veterinary Research 9:179.

Peachey L.E., Pinchbeck G.L., Scantlebury C.E., Tefera M., Getachew M., Etana D., Burden F.A., Trawford A.F., Matthews J.E., Hodgkinson J.E. (2014). The evaluation of African and UK bioactive plant extracts for the control of equid gastrointestinal nematodes. Journal of Equine Veterinary Science 32(10):S37-S38. (Conference abstract)

Williams A., Peachey L.E., Christley R.M. (2012). Assessment of a point-of-care test for measurement of blood triglyceride levels for rapid detection of equid hypertriglyceridaemia. Equine Veterinary Education vol. 24 (10) pp. 520.