Lajos Kalmar received his master’s degree in the Department of Veterinary Science of the Szent Istvan University in Hungary. He did his PhD at the Semmelweis University, Hungary in the Clinical and Experimental Immunology PhD program. During his undergraduate and PhD student period he works as an experimental geneticist searching for disease causing mutations in human. Between 2007 and 2015 he worked in the research group of Peter Tompa in the Institute of Enzymology, Hungarian Academy of Sciences, as a research associate. During this time he did bioinformatics analyses in the field of intrinsically disordered proteins, especially in the field of their evolution. In October 2015 he joined the research group of Dr. David Sargan as a post-doctoral scientist doing genetics and bioinformatics on dogs.
Subject groups/Research projects
Identify the genetic background of brachycephalic obstructive airway syndrome (BOAS).
I am interested in all kinds of natural and non-natural diversity, identification of evolutionary pathways and disease causing alterations in genes, and supplement the genomic information with structural (in protein), and functional data as well. I am particularly interested in genes and proteins having role in regulation, signal transduction and development.
I started my career as an experimental scientist than I turned to in silico methods, currently I am doing both and try to combine them to obtain more reliable and more interesting results.
Kovacs E, Tompa P, Liliom K, Kalmar L. Dual coding in alternative reading frames correlates with intrinsic protein disorder. Proc Natl Acad Sci U S A. 2010 Mar 23;107(12):5429-34.
Bergman P, Adori C, Vas S, Kai-Larsen Y, Sarkanen T, Cederlund A, Agerberth B, Julkunen I, Horvath B, Kostyalik D, Kalmár L, Bagdy G, Huutoniemi A, Partinen M, Hökfelt T. Narcolepsy patients have antibodies that stain distinct cell populations in rat brain and influence sleep patterns. Proc Natl Acad Sci U S A. 2014 Sep 2;111(35):E3735-44.
Tompa P, Schad E, Tantos A, Kalmar L. Intrinsically disordered proteins: emerging interaction specialists. Curr Opin Struct Biol. 2015 Sep 21;35:49-59.
Schad E, Kalmar L, Tompa P. Exon-phase symmetry and intrinsic structural disorder promote modular evolution in the human genome. Nucleic Acids Res. 2013 Apr;41(8):4409-22.
Hegyi H, Kalmar L, Horvath T, Tompa P. Verification of alternative splicing variants based on domain integrity, truncation length and intrinsic protein disorder. Nucleic Acids Res. 2011 Mar;39(4):1208-19.
Tusnády GE, Kalmár L, Simon I. TOPDB: topology data bank of transmembrane proteins. Nucleic Acids Res. 2008 Jan;36(Database issue):D234-9.
Kalmar L, Acs V, Silhavy D, Tompa P. Long-range interactions in nonsense-mediated mRNA decay are mediated by intrinsically disordered protein regions. J Mol Biol. 2012 Dec 7;424(3-4):125-31.
Kalmar L, Homola D, Varga G, Tompa P. Structural disorder in proteins brings order to crystal growth in biomineralization. Bone. 2012 Sep;51(3):528-34.
For full publication list, visit ResearcherID site