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Department of Veterinary Medicine

Cambridge Veterinary School

Studying at Cambridge

 

Dr Omar Rossi

Dr Omar Rossi

Research Associate


Office Phone: +44 (0) 1223765811

Biography:

Education

Mar. 2011 – Apr.2014 PhD, Novartis Institute for Biomedical Research (NIBR) - NVGH; Ph.D. program in Industrial and Molecular Biotechnology of the University of Naples Federico II – Thesis on “Modulation of reactogenicity of Generalized Modules for Membrane Antigens (GMMA) by genetic lipid A modification”. Supervisors: Dr. Christiane Gerke, Prof Calman MacLennan

Jul. 2010 State exam for the qualification as professional Biologist, Florence (Italy)

Feb. 2007 - Nov.2009 Master of Science (MSc) in Cellular and Molecular Biology (110/110 cum laude)University of Florence - Thesis on “Characterization of antimicrobial peptide’s isolate from salivary glands of Polistes dominulus larvae”. Supervisors: Prof. Luigia Pazzagli, Dr. Barbara Pantera

Oct 2003 - Feb. 2007 Bachelor of Science (BSc) in Biology (110/110 cum laude)University of Florence – Thesis on “Cloning of fragmented gene of Cerato-platanina, phitotoxic protein produced from Ceratocystis fimbriata”. Supervisors: Prof. Luigia Pazzagli, Prof. Gianni Cappugi

 

Professional experience

from Apr. 2015                Research Associate (Post-doctoral scientist), University of Cambridge – Department of veterinary medicine, studying the impact of antimicrobials on the within-host dynamics of bacterial infections. Supervisor: Dr Piero Mastroeni

Apr. 2014 – Apr. 2015      Post-doctoral scientist, Novartis Institute for Biomedical Research (NIBR) - Novartis Vaccines Institute for Global Health (NVGH) working on invasive Non-Typhoidal Salmonella and Neisseria meningitidis GMMA projects. Supervisor: Prof Calman A. MacLennan

Jan 2015 – March 2015   Visiting scientist at Wellcome Trust Sanger Institute working on Pathogen Genomics group under the supervision of Prof. Nicholas Thomson, Cambridge (UK)

Feb. 2014 – Mar. 2014    Visiting scientist at Wellcome Trust Sanger Institute working on Pathogen Genomic group under the supervision of Prof. Nicholas Thomson, Cambridge (UK)

Mar. 2011 – Apr.2014      Research scientist (during PhD program) at Novartis Institute for Biomedical Research (NIBR) working on Shigella GMMA project – NVGH; Supervisor: Dr. Christiane Gerke

Sep. 2010 – Feb. 2011    Internship at NIBR - NVGH involved in the “Shigella project” in Siena (Italy) 

Jan. – Jun. 2010             Laboratory technician at Entomon, working on extraction and commercialization of venom from Imenoptera for clinical, therapeutic, and diagnostic use

 

 

 

Subject groups/Research projects

Infection and Immunity:

Departments and Institutes

Wellcome Trust Sanger Institute:
Cambridge Infectious Diseases:
Research Associate

Research Interests

Study the impact of antimicrobials on the within-host dynamics of bacterial infections

Vaccines development

Keywords

  • Genomics
  • Shigella
  • Genetics
  • Molecular Biology
  • Host-Pathogen Interaction
  • Microbiology
  • Vaccines
  • Infectious disease dynamics
  • Infectious Diseases
  • Bioinformatics
  • Pathogens
  • Salmonella
  • Toll-like receptors
  • Resistance and immunity and infection
  • Antibiotic resistance
  • Whole genome sequencing
  • Bacteriology
  • Antimicrobial resistance
  • Innate Immunity
  • Drug discovery and vaccinology
  • TLR4
  • Salmonella enterica
  • Pattern Recognition Receptors

Key Publications

  • P. Mastroeni, O.      Rossi - Integrating immunology, epidemiology and mathematical      modelling towards a better understanding of invasive non-typhoidal Salmonella disease and rational      vaccination approaches – 2016 - Expert review of vaccines - DOI:10.1080/14760584.2016.1189330
  • O. Rossi, M. Caboni, A. Negrea, F.      Necchi, R. Alfini, F. Micoli, A. Saul, C.A. MacLennan, S. Rodini, C. Gerke      - TLR activation by Generalized Modules for Membrane Antigens (GMMA)      from lipid A mutants of Salmonella      enterica serovars Typhimurium and Enteritidis – 2016 – Clinical and      Vaccine Immunology, 23:304 –314 doi:10.1128/CVI.00023-16
  • L. Maggiore, L. Yu, U. Omasits, O. Rossi, G. Dougan, N. R. Thomson, A. Saul, J. Choudhary, C. Gerke - Quantitative proteomic analysis of Shigella flexneri and Shigella sonnei Generalized Modules for Membrane Antigens (GMMA) reveals highly pure preparations – 2015 - International Journal of Medical Microbiology, DOI: 10.1016/j.ijmm.2015.12.003.
  • C. Gerke, A. M. Colucci, C. Giannelli, S. Sanzone, C. G. Vitali, L. Sollai, O. Rossi, L. B. Martin, J. Auerbach, V. Di Cioccio, A. Saul - Production of a Shigella sonnei vaccine based on Generalized Modules for Membrane Antigens (GMMA), 1790GAHB – 2015 - PlosOne, volume 10(8) e0134478
  • O. Rossi and K.S. Baker, A. Phalipon, F.X. Weill, F. Citiulo, P. Sansonetti, C. Gerke, N.R. Thomson - Draft genomes of Shigella strains used by the STOPENTERICS consortium – 2015 - Gut Pathogens, volume 7:14, DOI 10.1186/s13099-015-00
  • M. Caboni, T. Pédron, O. Rossi, D. Goulding, D. Pickard, C.A. MacLennan, G. Dougan, N.R. Thomson, A. Saul, P.J. Sansonetti, C. Gerke - An O antigen capsule modulates bacterial pathogenesis in Shigella sonnei – 2015 – PlosPathogen, volume 11 (3) e10047
  • O. Rossi, L. Maggiore, O. Koeberling, F. Necchi, C.A. MacLennan, A. Saul, C. Gerke – Comparison of colorimetric assays with quantitative amino acid hydrolysis for quantifying proteins in Generalized Modules for Membrane Antigens (GMMA) – 2015 – Molecular Biotechnology, volume 57 (1) 84–93
  • O. Rossi, I. Pesce, C. Giannelli, S. Aprea, M. Caboni, F. Citiulo, S. Valentini, I. Ferlenghi, C.A. MacLennan, U.D’Oro, A. Saul, C. Gerke – Modulation of endotoxicity of Shigella Generalized Modules for Membrane Antigens (GMMA) by genetic lipid A modifications: relative activation of TLR4 and TLR2 pathways in different mutants - 2014 - Journal of Biological Chemistry, volume 289 (36) 24922–24935
  • O. Koeberling, E. Ispasanie, J. Hauser, O. Rossi, G. Pluschke, D. Caugant, A. Saul, C.A. MacLennan - A broadly protective vaccine against meningococcal disease in sub-Saharan Africa based on generalized modules for membrane antigens (GMMA) - 2014 -  Vaccine, volume 32 2688-2695
  • F. Berlanda Scorza, A. M. Colucci, L. Maggiore, S. Sanzone, O. Rossi, I. Ferlenghi, I. Pesce, M. Caboni, N. Norais, V. Di Cioccio, A. Saul, C. Gerke -  High yield production process for Shigella Outer Membrane Particles – 2012 - PlosOne, volume 7 (6) e35616