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Department of Veterinary Medicine

Cambridge Veterinary School

Studying at Cambridge

 

Dr Stefan de Vries

Dr Stefan de Vries

Research Associate

Dynamics of within host antibiotic resistance gene transfer.


Biography:

Stefan P. W. de Vries received his master’s degree (cum laude) in Medical Biology from the Radboud University Nijmegen, The Netherlands. Thereafter, did his PhD research in the Laboratory of Paediatric Infectious Diseases at the Radboud University Medical Centre, The Netherlands, studying molecular aspects of Moraxella catarrhalis pathogenesis. In April 2013 he joined the group of Prof. Dr. Duncan Maskell as a post-doctoral scientist to identify (novel) mechanisms responsible for survival of Campylobacter jejuni in the environment and during colonization of chickens. Currently his research is focussed on the dynamics of antibiotic resistance gene transfer during experimental infection. 

Subject groups/Research projects

Infection and Immunity:

Research Interests

I have a strong research interest in the mechanisms that pathogens use to cope with stress conditions, i.e. mechanisms that directly and indirectly contribute to antibiotic resistance, mechanisms that allow colonization/infection of host organisms or that enable the pathogen to survive in the environment. In particular, my research interest lies in the genetic basis of antibiotic resistance and in understanding the evolutionary path that has led to this resistance. I am interested in how we can use this knowledge to develop new or improved intervention strategies. 

Keywords

  • Antibiotic resistance
  • Genomics
  • Campylobacter jejuni
  • Host-pathogen interaction
  • Next-generation sequencing
  • Bacterial evolution
  • Expression profiling
  • Transposon mutant library screens
  • Whole genome sequencing
  • Bioinformatics
  • Salmonella

Key Publications

Earl JP*, de Vries SP*, Ahmed A, Powell E, Schultz MP, Hermans PW, Hill DJ, Zhou Z, Constantinidou CI, Hu FZ, Bootsma HJ, Ehrlich GD. Comparative genomic analyses of the Moraxella catarrhalis serosensitive and seroresistant lineages demonstrates their independent evolution. Genome Biology and Evolution. 2016 Feb Epub. *contributed equally to this work.

Mobegi FM, van Hijum SA, Burghout P, Bootsma HJ, de Vries SP, de Jongh CE, Simonetti E, Langereis JD, Hermans PW, de Jonge MI, Zomer A. From microbial gene essentiality to novel antimicrobial drug targets. BMC Genomics. 2014:15(1)958.

De Vries SP*, Bootsma HJ. Differential gene expression of Moraxella catarrhalis upon exposure to human serum. Genomics Data. 2014, 2:312-313. * corresponding author.

De Vries SP, Rademakers RJA, van der Gaast - de Jongh CE, Eleveld MJ, Hermans PWM, Bootsma HJ. Deciphering the genetic basis of Moraxella catarrhalis complement resistance: a critical role for the disulphide bond formation system. Mol Microbiol. 2014, 91(3):522-537.

De Vries SP, Eleveld ME, Hermans PW, Bootsma HJ. Characterization of the molecular interplay between Moraxella catarrhalis and human respiratory tract epithelial cells. PLoS One 8(8):e72193.

De Vries SP, Burghout P, Langereis JD, Zomer A, Hermans PW, Bootsma, HJ. Genetic requirements for Moraxella catarrhalis growth under iron-limiting conditions. Mol Microbiol. 2013, 87(1):14-29.

Zomer A*, de Vries SP*, Riesbeck K, Meinke AL, Hermans PW, Bootsma HJ. Genome sequence of Moraxella catarrhalis RH4, an isolate of seroresistant lineage. J Bacteriol. 2012, 194(24):6969. *contributed equally to this work.

Langereis JD, Stol K, Schweda EK, Twelkmeyer B, Bootsma HJ, de Vries SP, Burghout P, Diavatopoulos DA, Hermans PW. Modified lipooligosaccharide structure protects non-typeable Haemophilus influenzae from IgM-mediated complement killing in experimental otitis media. MBio 2012, 3(4):e00079-12.

Davie JJ, Earl J, de Vries SP, Ahmed A, Hu FZ, Bootsma HJ, Stol K, Hermans PW, Wadowsky RM, Ehrlich GD, Hays JP, Campagnari AA. Comparative analysis and supragenome modeling of twelve Moraxella catarrhalis clinical isolates. BMC Genomics. 2011, Jan 26;12:70.

Schaar V, de Vries SP, Perez Vidakovics ML, Bootsma HJ, Larsson L, Hermans PW, Bjartell A, Mörgelin M, Riesbeck K. Multicomponent Moraxella catarrhalis outer membrane vesicles induce an inflammatory response and are internalized by human epithelial cells. Cell Microbiol. 2010, 13(3):432-449.

De Vries SP, van Hijum SA, Schueler W, Riesbeck K, Hays JP, Hermans PW, Bootsma HJ. Genome analysis of Moraxella catarrhalis strain BBH18: a human respiratory tract pathogen. J Bacteriol. 2010, 192(14):3574-3583.

De Vries SP, Bootsma HJ, Hays JP, Hermans PW. Molecular aspects of Moraxella catarrhalis pathogenesis. Microbiol Mol Biol Rev. 2009, 73(3):389-406.