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Department of Veterinary Medicine

Cambridge Veterinary School

Studying at Cambridge

 

Alyce McClellan

Alyce McClellan

Graduate student - Supervisor Dr Barbara Blacklaws


Biography:

I am a BBSRC DTP student undertaking my PhD project at the Animal Health Trust, a charity which researches the prevention and treatment of disease and injury in companion animals. I studied Biomedical Science and completed a Masters at Royal Holloway, University of London before becoming a research assistant at the Animal Health Trust. We investigated the safety of using embryonic stem cells as a cellular treatment for tendon injury in horses as well as the impact of inflammation on tendon healing. After a brief break travelling for three months, I completed a 6-month Proof of Concept project at Cambridge investigating if a microtubule nucleating protein could be a viable target for new cancer drugs. My studentship will investigate the genetic risks that contribute to fracture by using RNA sequencing osteoblasts differentiated from induced pluripotent stem cells (iPSCs) from horses at high or low risk of fracture.

Subject groups/Research projects

Infection and Immunity:

Departments and Institutes

Animal Health Trust:

Research Interests

Pluripotent Stem Cells, Musculoskeletal Injury, Regenerative Medicine

Keywords

  • Pluripotent Stem Cells
  • Genetics
  • Musculoskeletal Injury
  • Fracture

Key Publications

McClellan, A., Paterson, Y., Paillot, R., Guest, D. (2019) Equine Fetal, Adult, and Embryonic Stem Cell-Derived Tenocytes Are All Immune Privileged but Exhibit Different Immune Suppressive Properties In Vitro. Stem Cells and Development

McClellan, A., Evans, R., Sze, C., Kan, S., Paterson, Y., Guest, D. (2019) A novel mechanism for the protection of embryonic stem cell derived tenocytes from inflammatory cytokine interleukin 1 beta. Scientific Reports

Baird, A., Lindsay, T., Everett, A., Iyemere, V., Paterson, Y., McClellan, A., Henson, F. and Guest, D. (2018). Osteoblast differentiation of equine induced pluripotent stem cells. Biology Open, 7(5