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Department of Veterinary Medicine

Cambridge Veterinary School

Studying at Cambridge


Jiro Sakai

Jiro Sakai

Supervisor - Dr Clare Bryant

Assessment of heterogeneity in Salmonella cell infection affecting signaling


After getting bachelor’s and master’s degree from Hokkaido University in Japan, I moved to Cambridge, Massachusetts in USA. I spent one year at MIT and the following three years at Harvard Medical School to pursue my scientific interest before I joined Dr. Bryant’s lab.


Thanks to a welcoming environment and highly motivated colleagues, I have been so happy so far since I came here. Besides, I was able to make a good friend with Leica confocal microscope (I used to use Olympus one) during the first year.

Outside of the lab I enjoy playing ice hockey and travelling burger shops (my favorite is BK! of course Mac is not bad though). I am basically happy with breads and chocolate spread.

Subject groups/Research projects

Infection and Immunity:

Research Interests

I am interested in the interaction between immune cells and bacteria to find a new therapeutic target in my future career. I investigate the effect of Salmonella infection on NF-κB signaling in macrophage. Salmonella invades macrophages with Salmonella Pathogenicity Island (SPI)-encoded effector proteins in order to survive and proliferate inside the host macrophages and subsequently spread to the whole body of the infected animal. NF-κB signaling plays a central role in regulating inflammatory responses of macrophages. While some of effector proteins are known to subvert NF-κB signaling, the Salmonella infection process has been elusive due to the complexity. The current research topic is to identify NF-κB oscillation pattern manipulated by Salmonella to untangle the complexity of the Salmonella infection.



  • Salmonella
  • NF-kB
  • TLR4
  • Macrophage

Collaborators outside this directory