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Department of Veterinary Medicine

Cambridge Veterinary School

Studying at Cambridge

 

Dr Lajos Kalmar

Dr Lajos Kalmar

Research Associate


Biography:

I received my master’s degree in the Department of Veterinary Science of the Szent Istvan University in Hungary and my PhD at the Semmelweis University. During my undergraduate and PhD student period I worked as an experimental geneticist searching for disease causing mutations in human. Between 2007 and 2015 I switched to the field of structural biology in the research group of Peter Tompa in the Institute of Enzymology, Hungarian Academy of Sciences. During this time I did bioinformatics analyses in the field of intrinsically disordered proteins, especially in the field of their evolution. In October 2015 I joined the Department of Veterinary Medicine and worked on canine genetics in the research group of Dr. David Sargan. In March of 2018 I joined the MRC-AMR research group led by Dr Mark Holmes and Dr Andrew Grant, and I have been working on the in vivo tracing and discovery of antimicrobial resistance genes.

Subject groups/Research projects

Genetics and Oncology:

Research Interests

Tracking antimicrobial resistance gene transfer in human and farm animal gut bacterial communities

Antimicrobial resistance (AMR) is an urgent and growing global public health threat. The controlled and uncontrolled usage of antibiotics in human medicine and in animal farming put selective pressure on the gut microbiota that leads to the continuous emergence of novel AMR genes, and their potential exchange between prokaryotic species. As a part of highly collaborative team my task is to build up and maintain the bioinformatics pipeline to analyse metagenomics and HiC sequencing data to trace the potential AMR gene transfers.

Keywords

  • Antibiotic resistance
  • Genomics
  • Genetics
  • Metagenomics
  • Functional evolution
  • Microbiotica
  • Horizontal gene transfer
  • Bacterial resistant
  • Disease causing alterations
  • Gut microbiome
  • Intrinsically disordered proteins
  • Whole genome sequencing
  • Genotype-phenotype correlations
  • Bioinformatics
  • Infectious Diseases
  • Genome sequencing

Key Publications

Kovacs E, Tompa P, Liliom K, Kalmar L. Dual coding in alternative reading frames correlates with intrinsic protein disorder. Proc Natl Acad Sci U S A. 2010 Mar 23;107(12):5429-34.

Bergman P, Adori C, Vas S, Kai-Larsen Y, Sarkanen T, Cederlund A, Agerberth B, Julkunen I, Horvath B, Kostyalik D, Kalmár L, Bagdy G, Huutoniemi A, Partinen M, Hökfelt T. Narcolepsy patients have antibodies that stain distinct cell populations in rat brain and influence sleep patterns. Proc Natl Acad Sci U S A. 2014 Sep 2;111(35):E3735-44.

Tompa P, Schad E, Tantos A, Kalmar L. Intrinsically disordered proteins: emerging interaction specialists. Curr Opin Struct Biol. 2015 Sep 21;35:49-59.

Schad E, Kalmar L, Tompa P. Exon-phase symmetry and intrinsic structural disorder promote modular evolution in the human genome. Nucleic Acids Res. 2013 Apr;41(8):4409-22.

Hegyi H, Kalmar L, Horvath T, Tompa P. Verification of alternative splicing variants based on domain integrity, truncation length and intrinsic protein disorder. Nucleic Acids Res. 2011 Mar;39(4):1208-19.

Tusnády GE, Kalmár L, Simon I. TOPDB: topology data bank of transmembrane proteins. Nucleic Acids Res. 2008 Jan;36(Database issue):D234-9.

Kalmar L, Acs V, Silhavy D, Tompa P. Long-range interactions in nonsense-mediated mRNA decay are mediated by intrinsically disordered protein regions. J Mol Biol. 2012 Dec 7;424(3-4):125-31.

Kalmar L, Homola D, Varga G, Tompa P. Structural disorder in proteins brings order to crystal growth in biomineralization. Bone. 2012 Sep;51(3):528-34.

For full publication list, visit ResearcherID site