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Department of Veterinary Medicine

Cambridge Veterinary School

Studying at Cambridge

 

Dr Ravin Jugdaohsingh

Biography:

I have a BSc (Imperial College London), MSc (University College London) and a PhD (King’s College London) in Chemistry. My PhD study was on characterizing the interactions between amorphous silica (soluble and polymeric/nanoparticulate) and aluminium to understand how silica could act as a natural antidote to aluminium toxicity (a potential bone, renal and neuro-toxin). Subsequently I carried out post-doctoral research at King’s College London and MRC Human Nutrition Research in Cambridge on dietary silicon intake and metabolism, and investigating its potential role in bone and connective tissue health.

Visiting worker at MRC Elsie Widdowson Laboratory (Cambridge, UK).

https://www.mrc-ewl.cam.ac.uk/

Subject groups/Research projects

Infection and Immunity:

Research Interests

My expertise is on the chemistry and biochemistry of silicon and the effect of the element on human health. I have a particular interest in the role and mechanisms of action of silicon in connective tissues as well as cell interactions and impact of mineral silica nanoparticles. Much of my work has been on bone, in understanding the role silicon may play in the maintenance of normal bone health.

Keywords

  • Bone health
  • Cell interactions
  • Silicon
  • Dietary intake
  • Chemistry

Key Publications

Ratcliffe S, Jugdaohsingh R, Vivancos J,Marron A, Deshmukh R, Ma JF,Mitani-Ueno N, Boekschoten MV, Müller M, Mawhinney RC, Kinrade SD, Isenring P, Bélanger RR, Powell JJ. Identification of a Mammalian Silicon Transporter. Am J Physiol Cell Physiol. 2017 May 1;312(5):C550-C561.

Quignard S, Coradin T, Powell JJ, Jugdaohsingh R. Silica nanoparticles as sources of silicic acid favoring wound healing in vitro. Colloids Surf B Biointerfaces. 2017 Jul 1;155:530-537.

Kalia P, Brooks RA, Kinrade SD, Morjan DJ, Brown AP, Rushton N, Jugdaohsingh R. Adsorption of amorphous silica nanoparticles onto hydroxyapatite surfaces differentially alters surface properties and adhesion of human osteoblast cells. PLoS One. 2016 Feb 10;11(2):e0144780

Jugdaohsingh R, Kessler K, Messner B, Stoiber M, Pedro LD, Schima H, Laufer G, Powell JJ, Bernhard D. Dietary Silicon Deficiency Does Not Exacerbate Diet-Induced Fatty Lesions in Female ApoE Knockout Mice. J Nutr 2015;145:1498-506.

Jugdaohsingh R, Watson A, Pedro LD, Powell JJ. The decrease in silicon concentration of the connective tissues with age in rats is a marker of connective tissue turnover. Bone 2015;75:40-48.

Jugdaohsingh R, Watson AIE, Bhattacharya P, van Lenthe GH, Powell JJ. Positive association between serum silicon levels and bone mineral density in female rats following oral silicon supplementation with monomethylsilanetriol. Osteoporos Int 2015;26:1405–1415.

Jugdaohsingh R, Calomme MR, Robinson K, Nielsen F, Anderson SHC, D’Hease P, Geutsens P, Loveridge N, Thompson RPH, Powell JJ. Increased longitudinal growth in rats on a silicon-depleted diet. Bone 2008;43:596-606.

Jugdaohsingh R, Tucker KL, Qiao N, Cupples LA, Kiel DP and Powell JJ (). Silicon intake is a major dietary determinant of bone mineral density in men and pre-menopausal women of the Framingham Offspring Cohort. J Bone Miner Res 2004;19:297–307.