skip to content
Home

Department of Veterinary Medicine

Cambridge Veterinary School
 

Departmental Seminars

Subscribe to Departmental Seminars feed
Termly seminar programme
URL: http://talks.cam.ac.uk/show/index/7282
Updated: 5 min 17 sec ago

Wed 15 May 16:00: How use of SSRI impacts placenta and mammary gland development Contact Fiona Roby for zoom link

Tue, 16/04/2024 - 10:08
How use of SSRI impacts placenta and mammary gland development

Selective serotonin reuptake inhibitors (SSRI) are the most commonly prescribed drug class in the US. Untreated depression during pregnancy creates a risk for maternal wellbeing and is coupled with adverse pregnancy outcomes with causes that are poorly understood and use of SSRI among pregnant women is increasing. Fluoxetine (Prozac) and sertraline (Zoloft) are the most prescribed medications for pregnant women in their first trimester. With nearly one in five women experiencing depression, SSRI use during pregnancy continues to increase in the US. Antenatal SSRI use has been demonstrated to also result in increased neonatal mortality and morbidity. Therefore, presenting a conundrum for medical care providers when making decisions as to how to treat pregnant women with depression and also protect the pregnancy, and health outcomes for the infant. Importantly, and often under looked, is that SSRI not only impact the neuronal serotonin transporter (SERT), but they also impact the effects of SERT throughout the body. Our work has recently demonstrated that treatment with fluoxetine prepartum results increased death of offspring and increased morbidity for the offspring that survive, which we have recapitulated in a sheep model. Further, our work demonstrates the SSRI also impact both mammary gland function and development, as well as maternal outcomes, recently demonstrating that use of fluoxetine increases adiposity in offspring up to 12 weeks of age, and that male offspring appear to be disproportionally affected. We continue to investigate the impact of SSRI use on the placenta, mammary gland development, and long-term effects on both dam and offspring. Our goal is to develop novel interventions that will allow the dam to continue SSRI treatment if needed that will not impact her long-term health, as well as the long-term health of the offspring.

Contact Fiona Roby for zoom link

Add to your calendar or Include in your list

Wed 15 May 16:00: How use of SSRI impacts placenta and mammary gland development

Mon, 15/04/2024 - 12:03
How use of SSRI impacts placenta and mammary gland development

Selective serotonin reuptake inhibitors (SSRI) are the most commonly prescribed drug class in the US. Untreated depression during pregnancy creates a risk for maternal wellbeing and is coupled with adverse pregnancy outcomes with causes that are poorly understood and use of SSRI among pregnant women is increasing. Fluoxetine (Prozac) and sertraline (Zoloft) are the most prescribed medications for pregnant women in their first trimester. With nearly one in five women experiencing depression, SSRI use during pregnancy continues to increase in the US. Antenatal SSRI use has been demonstrated to also result in increased neonatal mortality and morbidity. Therefore, presenting a conundrum for medical care providers when making decisions as to how to treat pregnant women with depression and also protect the pregnancy, and health outcomes for the infant. Importantly, and often under looked, is that SSRI not only impact the neuronal serotonin transporter (SERT), but they also impact the effects of SERT throughout the body. Our work has recently demonstrated that treatment with fluoxetine prepartum results increased death of offspring and increased morbidity for the offspring that survive, which we have recapitulated in a sheep model. Further, our work demonstrates the SSRI also impact both mammary gland function and development, as well as maternal outcomes, recently demonstrating that use of fluoxetine increases adiposity in offspring up to 12 weeks of age, and that male offspring appear to be disproportionally affected. We continue to investigate the impact of SSRI use on the placenta, mammary gland development, and long-term effects on both dam and offspring. Our goal is to develop novel interventions that will allow the dam to continue SSRI treatment if needed that will not impact her long-term health, as well as the long-term health of the offspring.

Add to your calendar or Include in your list

Wed 05 Jun 13:00: Title to be confirmed

Mon, 08/04/2024 - 13:22
Title to be confirmed

Chaired by Cassia Hare

Add to your calendar or Include in your list

Wed 15 May 16:00: How use of SSRI impacts placenta and mammary gland development

Mon, 08/04/2024 - 13:12
How use of SSRI impacts placenta and mammary gland development

Laura L. Hernandez, Professor-Lactation Physiology Department of Animal and Dairy Sciences University of Wisconsin-Madison

Add to your calendar or Include in your list

Wed 05 Jun 16:00: Title to be confirmed

Wed, 27/03/2024 - 13:40
Title to be confirmed

Chaired by Cassia Hare

Add to your calendar or Include in your list

Tue 23 Jul 16:00: Active Surveillance of Neglected Tropical Diseases: A Fresh Push to Identify Reservoir Hosts

Fri, 22/03/2024 - 15:08
Active Surveillance of Neglected Tropical Diseases: A Fresh Push to Identify Reservoir Hosts

Abstract: The recent wave of pandemic/epidemics in the world has necessitated that Africa join the global push to not only to be ready for future pandemics but to also preempt them. Africa is plagued with a lot of neglected tropical diseases, many of them caused by neurotropic viruses. With minimal funding of these diseases, the burden they create on quality of life and productivity of animals has not been well estimated. More important is the need for active surveillance of possible reservoir hosts for some of these Neglected Tropical Diseases, so as to proper understand their epidemiology. In this presentation, I will be speaking on West Nile, and Crimean Congo Heamorrhagic Fever viruses, and the roles that reservoirs may be playing for reverse zoonosis.

Short Citation: James Olukayode Olopade graduated with the DVM (Veterinary) degree in 1992 and obtained his MSc and PhD in 2003 and 2006, respectively, all from the University of Ibadan. He was promoted full Professor in 2011. James carried out postdoctoral trainings in Marine Biology Laboratory Woodshole, USA , as an International Brain Research Organisation (IBRO) Fellow at Penn State University, USA in 2008, and as a MacArthur and Alexander von Humboldt Fellow, both at the University of Wurzburg, Germany. He has served as Editor in Chief, Nigerian Veterinary Journal and Dean, Faculty of Veterinary Medicine. His current research areas are in neuroscience, comparative anatomy and surveillance biology. He has been funded by a variety of organisations including the International Society of Neurochemistry; the International Brain Research Organisation, the Alexander von Humboldt Foundation; the Tertiary Education Trust Fund, Nigeria, and the Cambridge Alborada Grant (UK) amongst others. He has over 160 research publications including 4 copyrights and is the most cited veterinarian in Africa as per brain research. James Olopade is currently the Principal Investigator of Alexander von Humboldt Research Hub for Zoonotic Arboviral Diseases (HRH-ZAD), a €750,000 Humboldt Research Hub funding for pandemic preparedness, and also the Director of the Veterinary Teaching Hospital, at the University of Ibadan in Nigeria.

Add to your calendar or Include in your list

Wed 15 May 12:00: How use of SSRI impacts placenta and mammary gland development

Mon, 18/03/2024 - 16:42
How use of SSRI impacts placenta and mammary gland development

Laura L. Hernandez, Professor-Lactation Physiology Department of Animal and Dairy Sciences University of Wisconsin-Madison

Add to your calendar or Include in your list

Wed 15 May 12:00: Title to be confirmed

Mon, 18/03/2024 - 10:04
Title to be confirmed

Laura L. Hernandez, Professor-Lactation Physiology Department of Animal and Dairy Sciences University of Wisconsin-Madison

Add to your calendar or Include in your list

Tue 23 Jul 16:00: Title to be confirmed

Mon, 18/03/2024 - 09:57
Title to be confirmed

Chaired by Dr Raymond Bujdoso

Add to your calendar or Include in your list

Wed 15 May 12:00: Title to be confirmed

Fri, 08/03/2024 - 17:01
Title to be confirmed

Laura L. Hernandez, Ph.D. (she, her, hers) Professor-Lactation Physiology Department of Animal and Dairy Sciences Affiliate Professor-Obstetrics and Gynecology

Chaired by Dr Kate Hughes

Add to your calendar or Include in your list

Fri 19 Jan 12:00: Modelling optimal intervention strategies for animal diseases in data poor settings This talk will be streamed and will be accessible remotely once it has started, with raven login here: https://cambridgelectures.cloud.panopto.eu...

Mon, 15/01/2024 - 09:21
Modelling optimal intervention strategies for animal diseases in data poor settings

Abstract: Emerging diseases of livestock can devastate the agricultural industry and have a severe impact upon livestock exports. It is therefore vital to provide tools to assess the risk associated with infectious diseases and establish surveillance and intervention protocols that will reduce the cost of such outbreaks in the future. In this presentation, I will discuss the role of infectious disease models in supporting contingency planning for livestock disease outbreaks. These models typically require data on locations, sizes and species compositions of farms, as well as detailed information on any animals that are infected with the disease. However, in many settings such data are not available. I will therefore demonstrate how models can support infectious disease control in settings where such detailed data are not accessible and how surveillance resources should be targeted to reduce model uncertainty and provide accurate predictions regarding the future spread of disease.

Bio: Prof. Mike Tildesley is a Professor of Infectious Disease Modelling at the University of Warwick. He has an interest in the predictive power of models in the early stages of emerging disease outbreaks and in communicating modelling results to policy advisors. He has extensive experience of modelling livestock disease systems, including Foot-and-Mouth Disease (FMD) and Highly Pathogenic Avian Influenza (HPAI). Prof. Tildesley has advised the UK Government’s Department for the Environment, Food and Rural Affairs, the US Department of Agriculture and the Food and Agriculture Organisation of the United Nations about strategies for control of livestock diseases including FMD and HPAI . From March 2020 to March 2022, He was a member of the Scientific Pandemic Influenza Modelling Operational group (SPI-M-O), and worked extensively on COVID -19, providing policy advice to the UK government.

This talk will be streamed and will be accessible remotely once it has started, with raven login here: https://cambridgelectures.cloud.panopto.eu/Panopto/Pages/Sessions/List.aspx#folderID=%220c72d750-7bc0-4938-88f2-ae7c00b8c25d%22

Add to your calendar or Include in your list

Contact us

Department of Veterinary Medicine
Madingley Road
Cambridge
CB3 0ES

Telephone and Enquiries Email

Site Privacy & Cookie Policies

 

 

Study at Cambridge

About the University

Research at Cambridge