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Department of Veterinary Medicine

Cambridge Veterinary School
 

Infectious disease epidemiology and the impact of immunisation

I am an infectious disease epidemiologist with a particular interest in vaccine evaluation. Most of my work is on human diseases, in particular meningococcal disease, but my research encompasses a range of other infections including rabies, pneumococcus, Hib, group B streptococcus, HPV, rotavirus, and norovirus. I use a variety of methods, including field studies, observational studies, mathematical modelling and cost-effectiveness. I enjoy addressing questions of direct relevance to vaccine and public health policy.

I  am a member of the Vaccine Impact Modelling Consortium (VIMC). I work with Public Health England's Immunisation Department and collaborate with the World Health Organisation. 

Biography

I am an infectious disease epidemiologist, based in the Disease Dynamics Unit.I obtained my first degree in Human Sciences from the University of Oxford, followed by an MSc and PhD in Infectious Disease Epidemiology at the London School of Hygiene and Tropical Medicine. I worked at the Health Protection Agency and then the University of Bristol before moving to Cambridge in January 2013. I am an honorary epidemiologist in Public Health England's Immunisation Department.

Research

My research concentrates on understanding the epidemiology of vaccine-preventable diseases and the impact of immunisation. The majority of my work is on meningococcal infection, but I am also involved in research on pneumococcus, group B streptococcus, rotavirus and human papillomavirus. I use a range of methods including analysis of large databases, systematic reviews, prospective clinical/ field studies, health economics, seroprevalence studies and mathematical modelling. I am most interested in applying these methods to research questions of direct relevance for vaccine policy.

I  work with the African Meningococcal Carriage Consortium (MenAfriCar), a global research effort to study how meningococcal meningitis is spread in Africa, and to document the impact of a new meningitis vaccine (MenAfriVac) on reducing transmission. 

I also work on collaborative projects with Public Health England, University of Bristol, St Georges University of London, Agence de Medicine Preventive and the World Health Organisation. 

Click for details of Meningitis Research Foundation funded projects on cost-effectiveness of GBS vaccines, persistence of MenAfriVac, use of MenAfriVac in pregnant women and how people value the benefits of vaccination.

Publications

Key publications: 

Google Scholar - link to all publications

Li X, Mukandavire C, Cucunuba ZM et al, Vaccine Impact Modelling Consortium. Estimating the health impact of vaccination against ten pathogens in 98 low-income and middle-income countries from 2000 to 2030: a modelling study. Lancet. 2021 Jan 30;397(10272):398-408. doi: 10.1016/S0140-6736(20)32657-X

Cooper LV, Ronveaux O, Fernandez K, Lingani C, Goumbi K, Ihekweazu C, Preziosi M-P, Durupt A, Trotter CL. Spatio-temporal analysis of serogroup C meningococcal meningitis spread in Niger and Nigeria and implications for epidemic response. J Infect Dis 2019, Oct 31;220(Supplement_4)

WHO Rabies Modelling Consortium (Corresponding authors Trotter CL, Hampson K). The potential impact of improved provision of rabies post-exposure prophylaxis in Gavi-eligible countries: a modelling study. Lancet Infectious Diseases, 2018, Nov 21. pii: S1473-3099(18)30512-7. doi: 10.1016/S1473-3099(18)30512-7

Trotter CL, Lingani C, Fernandez K, Cooper LV, Bita A, Tevi-Benissan C, Ronveaux O, Preziosi MP, Stuart JM. The impact of MenAfriVac in nine countries of the African meningitis belt, 2010-2015: an analysis of surveillance data. Lancet Infect Dis 2017, pii: S1473-3099(17)30301-8

Principal Research Associate in Epidemiology
Fellow of Hughes Hall

Contact Details

Email address: 
+44 1223 765631
Takes PhD students
Available for consultancy

Affiliations

Classifications: 
Specialities: 
Local Affiliations: 
Person keywords: 
Mathematical modelling
Epidemic control
Vaccines
Epidemiology
Bacterial meningitis
Infectious Diseases
Funding: 
Meningitis Research Foundation 
Public Health England
World Health Organisation