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Dr Thippesh Sannasiddappa

Dr Thippesh Sannasiddappa

Research associate


Biography:

Thippesh Sannasiddappa completed his Bachelor’s and Master’s in Veterinary Science (India) before moving to Reading in 2009.  He was enrolled in a PhD programme (Molecular Microbiology) under Dr. Simon R. Clarke’s supervision at the School of Biological Sciences, University of Reading. During his PhD, he researched on Staphylococcus aureus virulence factors involved in the intestinal colonization using in vitro human colonic model.  He then joined microbial stress response group headed by Dr. Peter Lund at Institute of Microbiology and Infection, University of Birmingham as Postdoctoral Research Associate in November 2013. He worked on urinary pathogenic E. coli stress response to diverse environmental conditions using Transposon sequencing and RNA-sequencing methods in Dr. Lund group. In October 2016, he joined Dr. Andrew Grant group (bacterial infection group) at Department of Veterinary Medicine.  His current research mainly focuses on development and evaluation of novel multivalent glycoconjugate veterinary vaccines for bacterial infections.

Subject groups/Research projects

Infection and Immunity:

Research Interests

Being a Molecular Microbiologist, I have a keen interest towards understanding pathogenesis of bacterial infections in the host and their survival in the environment at a molecular level.  Currently I am using molecular genetics, biochemistry, next generation sequencing, glycol-engineering and vaccinology tools to develop and evaluate multivalent vaccines for poultry bacterial infections caused by Campylobacter jejuni, Salmonella Typhimurium, Avian pathogenic E. coli and Clostridium perfringens. I have also interest in understanding antimicrobial resistance, developing tools to identify antimicrobial resistance and development of novel antimicrobial agents.

Keywords

  • Bacterial pathogenesis
  • Antimicrobial resistance
  • Innate immunity
  • Vaccines
  • Glycoengineering
  • Genome sequencing

Key Publications

Sannasiddappa TH, Hood G, Hanson K, Costabile A, Gibson G and Clarke SR. (2015). Staphylococcus aureus MnhF mediates cholate efflux and facilitates survival under human colonic conditions. Infection and Immunity, 83(6): 2350-2357.

Sannasiddappa TH, Costabile A, Gibson GR and Clarke SR. (2011). The influence of Staphylococcus aureus on gut microbial ecology in an in vitro continuous culture human colonic model system. PLoS ONE, 6 (8):E23227

Thippeswamy, HS and Kaul, G. (2011) Role of heat shock proteins in diseases and their therapeutic potential. Indian Journal of Microbiology, 51(2):124-131.

Thippeswamy HS, Sood SK, Venkateswaralu R and Isha Raj. (2009). Membranes of five-fold alamethicin-resistant Staphylococcus aureus, Enterococcus faecalis and Bacillus cereus show decreased interactions with alamethicin due to changes in membrane fluidity and surface charge. Annals of Microbiology, 59(3):593-601.

Kaul G, Mohan Kumar D and Thippeswamy HS. (2009) Detection of IGF-I receptor on caprine spermatozoa by RT-PCR method. Indian Journal of Dairy Science, 62(4):275-279.