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Department of Veterinary Medicine

Cambridge Veterinary School

Prion diseases are infectious and transmissible protein misfolding neurodegenerative diseases of mammals. The research group of Dr Raymnod Bujdoso have developed PrP transgenic Drosophila as an invertebrate model of authentic prion disease. My research project is focussing on studying the gene expression changes that occur during prion disease in this model system to investigate the pathogenic processes occuring.


Andrew undertook his undergraduate degree in Natural Sciences at the University of Cambridge from 2016-2019, specialising in Pathology in Part II. Since 2019, Andrew has been a BBSRC Doctoral Training Partnership (DTP) PhD student in the Department of Veterinary Medicine, University of Cambridge, and his project focuses on studying gene expression changes in Drosophila models of prion diseases.


Key publications: 

Bujdoso R, Smith A, Fleck O, Spiropoulos J, Andréoletti O, Thackray AM. Prion disease modelled in Drosophila. Cell Tissue Res. 2022 Jan 29. doi: 10.1007/s00441-022-03586-0. Epub ahead of print. PMID: 35092497.

Frankel D, Davies M, Bhushan B, Kulaberoglu Y, Urriola-Munoz P, Bertrand-Michel J, Pergande MR, Smith AA, Preet S, Park TJ, Vendruscolo M, Rankin KS, Cologna SM, Kumita JR, Cenac N, St John Smith E. Cholesterol-rich naked mole-rat brain lipid membranes are susceptible to amyloid beta-induced damage in vitro. Aging (Albany NY). 2020 Nov 4;12(21):22266-22290. doi: 10.18632/aging.202138. Epub 2020 Nov 4. PMID: 33147569; PMCID: PMC7695401.

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