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Department of Veterinary Medicine

Cambridge Veterinary School

I am a senior research associate with an interest in microbial functional genomics, in particular Klebsiella pneumoniae and other Enterobacteriaceae species (Salmonella Typhimurium, Enterobacter cloacae).

I am using different sequencing-based methods to understand how the human pathogen Klebsiella pneumoniae interacts with the immune system, in particular macrophages.


After graduating from the Technical University of Braunschweig/Germany, I joined to lab of Susanne Häussler at the Helmholtz Centre for Infection Research. During my PhD I used deep transcriptomic sequencing (RNA-seq) to study Antimicrobial Resistance in Pseudomonas aeruginosa and Klebsiella pneumoniae. Followed by a short post-doc in the same group where I developed rapid molecular diagnostics to detect hospital outbreaks and antibiotic resistance in several different bacterial species (mainly, Pseudomonas aeruginosa, Klebsiella pneumoniae, Escherichia coli and Clostridium difficile). In 2017, I took up a post as a postdoctoral fellow in the Parkhill group at the Wellcome Sanger Institute using Functional Genomics (RNA-sequencing and transposon-directed insertion site sequencing, TraDIS) to understand the antimicrobial stress response in the Enterobacteriaceae species Klebsiella, Salmonella and Enterobacter.


Host-Pathogen Interactions and Antimicrobial Resistance of Gram negative bacteria, in particular Klebsiella pneumoniae


Key publications: 

Identifying virulence determinants of multidrug-resistant Klebsiella pneumoniae in Galleria mellonella
S Bruchmann, T Feltwell, J Parkhill, FL Short
Pathogens and disease 79 (3), ftab009

Deep transcriptome profiling of clinical Klebsiella pneumoniae isolates reveals strain and sequence type‐specific adaptation
S Bruchmann, U Muthukumarasamy, S Pohl, M Preusse, A Bielecka, ...
Environmental microbiology 17 (11), 4690-4710

Discordant bioinformatic predictions of antimicrobial resistance from whole-genome sequencing data of bacterial isolates: an inter-laboratory study
RM Doyle, DM O'sullivan, SD Aller, S Bruchmann, T Clark, AC Pelegrin, ...
Microbial genomics 6 (2)

Spatiotemporal control of FlgZ activity impacts Pseudomonas aeruginosa flagellar motility
S Bense, S Bruchmann, A Steffen, TEB Stradal, S Häussler, J Düvel
Molecular Microbiology 111 (6), 1544-1557

Importance of flagella in acute and chronic Pseudomonas aeruginosa infections
A Lorenz, M Preuße, S Bruchmann, V Pawar, N Grahl, MC Pils, LM Nolan, ...
Environmental microbiology 21 (3), 883-897

BACTOME—a reference database to explore the sequence- and gene expression-variation landscape of Pseudomonas aeruginosa clinical isolates
K Hornischer, A Khaledi, S Pohl, M Schniederjans, L Pezoldt, F Casilag, ...
Nucleic acids research 47 (D1), D716-D720

Transcriptome profiling of antimicrobial resistance in Pseudomonas aeruginosa
A Khaledi, M Schniederjans, S Pohl, R Rainer, U Bodenhofer, B Xia, ...
Antimicrobial agents and chemotherapy 60 (8), 4722-4733

Other publications: 
Senior Research Associate

Contact Details

Takes PhD students
Not available for consultancy


Collaborator profiles: 
Local Affiliations: 
Medical Research Council