skip to primary navigationskip to content

Department of Veterinary Medicine

Cambridge Veterinary School

Studying at Cambridge

 

Oliver Fleck

Oliver Fleck

Supervisor: Dr Raymond Bujdoso


Biography:

2018 – present:

PhD Biosciences (BBSRC DTP), Department of Veterinary Medicine, University of Cambridge, UK.

2016 – 2018:

MPhil Bioengineering, Department of Engineering, University of Cambridge, UK.

2013 – 2014:

MRes Bioengineering, Department of Bioengineering, Imperial College London, UK.

2010 – 2013:

BSc (Hons) Biomedical Sciences, School of Biomedical and Biological Sciences, University of Plymouth, UK.

Subject groups/Research projects

Infection and Immunity:

Research Interests

My research interests lie primarily in neurodegenerative diseases, with particular focus on disorders that occur through protein misfolding. The unique properties of prion proteins and their role in disease manifestation provides a fascinating and complex research topic, having implications in wider problems facing modern healthcare.

 

Due to the issues presented by aging populations, the burden presented by neurodegenerative diseases has become an increasingly pressing problem in recent years. While prion diseases are unique among these disorders for being transmissible, they act as an important model and basis for research into other diseases. Due to their transmissible nature, prion diseases represent a threat to modern food security and infrastructure. Therefore, the further understanding of these diseases is essential.

 

During my time here, I aim to address some of the outstanding questions within protein misfolding research, by engaging multidisciplinary techniques to characterise protein aggregation, and the effects within Drosophila genetic expression.

 

Keywords

  • Protein misfolding
  • Neurodegeneration
  • PrP
  • Drosophila

Key Publications

  • Fleck, O., and T. Savin. "A physical approach to model occlusions in the retinal microvasculature." Eye (2018).
  • Kis, Z., Rodin, T., Zafar, A., Lai, Z., Freke, G., Fleck, O., Hernandez, A.D.R., Towhidi, L., Pedrigi, R.M., Homma, T. and Krams, R., 2016. Development of a synthetic gene network to modulate gene expression by mechanical forces. Scientific reports6, p.29643.