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Department of Veterinary Medicine

Cambridge Veterinary School

Studying at Cambridge

 

Dr George Carnell

Dr George Carnell

Research Associate


Biography:

George read Biology with Microbiology at Imperial College, and then completed an MSc at the London School of Hygiene and Tropical Medicine in Medical Microbiology (Virology).  George completed his PhD in 2017 at the Medway School of Pharmacy under the supervision of Dr Nigel Temperton, Dr Simon Scott and Prof Sarah Gilbert (Jenner inst. Oxford).  His project primarily involved the production of lentiviral pseudotypes bearing glycoproteins from various influenza subtypes and strains, as well as the production and application of a chimeric haemagglutinin pseudotype system for the detection of HA stalk directed, neutralising antibodies.  His current work still involves the influenza virus as well as Lassa and Ebola viruses, with aims towards the production and testing of broadly protective vaccines.

 

Subject groups/Research projects

Infection and Immunity:

Research Interests

Primary interests surround the use of viruses as tools, in particular with regard to the production of vaccines, gene therapy applications and next generation assays for immunogenicity testing.

Keywords

  • Pseudotypes
  • Molecular Biology
  • Virology
  • Neutralisation assay
  • Zoonoses
  • Universal vaccine

Key Publications

Giotis, E. S., Carnell, G. W., Young, E. F., Ghanny, S., Soteropoulos, P., Barclay, W. S., Skinner, M. A., Temperton, N. J. (2019). The MHC class-II HLA-DR receptor mediates bat influenza A-like H17N10 virus entry into mammalian cells. bioRxiv. http://dx.doi.org/10.1101/507467

Carnell, G. W., Giotis, E. S., Grehan, K., Ferrara, F., Mather, S., Molesti, E., Scott, S., Pessi, A., Lacek, K., Temperton, N, J. (2018).The bat influenza H17N10 can be neutralised by broadly-neutralising monoclonal antibodies and its neuraminidase facilitates viral egress. bioRxiv. doi: https://doi.org/10.1101/499947

Dong, W., Bhide, Y., Sicca, F., Meijerhof, T., Guilfoyle, K., Engelhardt, O. G., Boon, L., De Haan, C. A., Carnell, G. W., Temperton, N. J., de Vries-Idema, J., Kelvin, D., Huckriede, A. (2018). Cross-protective immune responses induced by sequential influenza virus infection and by sequential vaccination with inactivated influenza vaccines. Frontiers in Immunology. doi: 10.3389/fimmu.2018.02312

Thompson, C. P., Lourenco, J., Walters, A. A., Obolski, U., Edmans, M., Palmer, S. D., Kooblall, K., Carnell, G. W., Connor, D. O., Bowden, T. A., Pybus, O. G., Pollard, A. J., Temperton, N. J., Lambe, T., Gilbert, S. G., Gupta, S. (2018). A naturally protective epitope of limited variability as an influenza vaccine target. Nat Commun. 2018;9(1):3859. doi:10.1038/s41467-018-06228-8

Valkenburg, S. A., Mallajosyula, V. V. A., Li, O. T. W., Chin, A. W. H., Carnell, G. W., Temperton, N. J., Varadarajan, R., Poon, L. L. M. (2016). Stalking influenza by vaccination with pre-fusion headless HA mini-stem. Scientific Reports. 6: 1-11. doi: 10.1038/srep22666.

Carnell, G. W., Ferrara, F., Grehan, K., Thompson, C. P., Temperton, N. J. (2015). Pseudotype-based neutralization assays for influenza: A systematic analysis. Frontiers in Immunology. 6(MAR): 1- 17. doi: 10.3389/fimmu.2015.00161.